Analysis Of The Clinical Characteristics For Hepatitis B Virus Related Hepatocellular Carcinoma And Alcohol Related Hepatocellular Carcinoma

Objective: To compare the differences in clinical characteristics between hepatitis B virus related hepatocellular carcinoma(HCC)and alcohol related HCC,as well as evaluate whether these clinical characteristics are associated with the subtype of HCC.Methods: 271 cases of HCC patients were collected in the fourth hospital of Hebei Medical University from January 1,2011 to December 31,2016,who were divided into two groups as HBV-HCC(n=215)and alcohol-HCC(n=56)based on whether they were infected with hepatitis B virus or alcohol abuse.The clinical data including age,gender,ALT,AST,GGT,TBIL,ALB,Child-Pugh classification,AFP,subtype of image classification,tumor quantity,and portal vein tumor thrombosis were evaluated in the two different groups.The student’s t-test was used for quantitative variable and the chi-square test or Fisher’s exact test was used for qualitative variable.All analyses were performed using SPSS software(version 21.0),and a P-value﹤0.05 was considered statistically significant.Results:1.There was no difference of distribution frequency referring to age between HBV-HCC and alcohol-HCC(?2=2.088,P=0.148),whereas the distribution frequency for gender was significantly different in these two subtypes with more male patients in alcohol-HCC(?2=9.117,P=0.001).2.There was no difference of distribution frequency in terms of ALT,AST,TBIL,Child-Pugh classification between the two subtypes(P﹥0.05),whereas GGT,ALB and AFP were significantly different.The level of GGT increased significantly in alcohol-HCC subtypes(t=-2.518,P=0.014).Compared with alcohol-HCC,a lower level of ALB(t=-2.422,P=0.016)and a increased AFP was found in HBV-HCC(?2=15.881,P=0.000).3.HCC was divided into four subtypes basing imaging classification including diffuse HCC,small HCC,nodular HCC and massive HCC according to China classification standard.Imaging analysis including subtype of image classification,tumor quantity,and portal vein tumor thrombosis were performed in 104 cases of HBV-HCC and 29 cases of alcohol-HCC,no difference exist in the two groups(P﹥0.05).Conclusion:1.More Male patients in alcohol-HCC subtype demonstrated the influence of lifestyle on disease.The fact that alcohol is the mitochondrial enzyme inducer of hepatocyte to promote the synthesis and release of GGT could explain the increased GGT levels in alcohol-HCC.The low ALB in HBV-HCC implied that the HBV could severely destroy the synthesis function of liver.The obviously increased AFP in HBV-HCC implied the different signal transduction pathway initiated by these two types.2.The two subtypes of HCC are indistinguishable in terms of image classification,tumor quantity,and portal vein tumor thrombosis.