Expression Of CHD1L In Glioma And Its Relationship With Clinicopathological Factors

Objective:The Chromodomain helicase/ATPase DNA binding protein 1-like gene(CHD1L)is a newly discovered gene which is located on the chromosome 1q21.It has been reported that abnormally high expression CHD1 L has been detected in various malignancies.However,the expression and significance of CHD1 L in glioma is still unclear,the purpose of this study is to investigate the expression of CHD1 L and its relationship with clinicopathological features in glioma patients.Method:120 cases of gliomas were selected from 2006 to 2011 with WHO classification grade I-IV.The expression level of CHD1 L in gliomas was detected by immunohistochemical staining.The relationship between the expression of CHD1 L and clinicopathological features in glioma patients was analyzed by Chi-Squared Test.The relationship between CHD1 L and the prognosis of the patients was tested by KaplanMeier analysis.Results:CHD1L was highly expressed in gliomas,and its high expression was positively correlated with the tumors size,WHO grade and Ki-67 index(P <0.05),but not negatively correlated with age,gender and tumor location.The Kaplan-Meier curve showed that the high expression of CHD1 L was positively correlated with the poor prognosis of glioma patients.Conclusion :CHD1L is highly expressed in gliomas and is positively correlated with tumor size,WHO grade,Ki-67 index and poor prognosis.CHD1 L may play a role in the development and progression of glioma.