| Objective : Gastric cancer is one of the most common malignant tumors in the digestive system,and its incidence is also very high in China.The incidence of gastric cancer in our country is on the rise in recent years.The first choice of treatment for gastric cancer is surgery.The effect of the operation is limited by the method of operation and the scope of resection and so on.The enlargement of the scope of operation is bound to lead to an increase in postoperative complications such as lymphatic leakage,bleeding,increased side injury,and so on.In the opposite direction,narrowing the scope of operation will not reach the expected therapeutic effect.In order to have a certain significance for the patient to carry out individualized treatment,it is important to looking for a way to provide the progression and metastasis of the patient’s tumor before the operation.This study was to discuss the relationship between lymph node metastasis and the following aspects as NLR in peripheral blood,lymphocyte in tissue of gastric cancer,and the expression of P53 and Ki67.We hope to find a relatively simple method to help us to judge the progression and metastasis of the tumor and to guide the selection of surgical methods.Method: We did research on 117 cases of gastric cancer patients in our hospital.Peripheral blood NLR was calculated before operation.After operation,the lymphocyte counts of gastric cancer tissue,para cancerous tissue and normal gastric tissue were taken under microscope,and the expression of P53 and Ki67 in gastric cancer tissue was detected.Results: 1.The NLR of the early gastric cancer patients is 3.14 ± 1.72,and the NLR in the advanced gastric cancer patients is 4.54 ± 2.63.There is a significant difference between the two(P<0.05).The NLR in the patients with lymph node metastasis is4.48 ± 2.83,and the NLR in the patients without lymph node metastasis is 3.67 ± 1.76.There is no significant differencebetween the two(P>0.05).2.The lymphocyte count in the para cancerous tissue was higher than that of gastric cancer tissue and normaltissue,and the difference is statistically significant.However,there is no statistically significance in lymphocyte count between gastric cancer tissues and normal tissues.The lymphocyte count in para tissue of advanced gastric cancer is higher than that in para tissue ofearly gastric cancer,and the difference is statistically significant.The lymphocyte count in gastric cancer tissues with lymph node metastasis is higher than that without lymph node metastasis.The result is statistically significant(P<0.05).There is no significant difference in lymphocyte count between the cancer tissues and normal tissues without lymph node metastasis(P>0.05).3.The positive expression of P53 and Ki67 in gastric cancer tissues was significantly different from the clinical stage,infiltration depth and lymph node metastasis(P<0.05).Conclusion:Peripheral blood NLR is higher in patients with advanced gastric cancer than in early gastric cancer patients,but it is not related to lymph node metastasis.In cases of lymph node metastasis and advanced gastric cancer,the lymphocyte count in the gastric cancer tissues and para cancerous tissues both increased,especially in the side of the gastric cancer tissues.P53 and Ki67 are highly expressed in patients with late clinical stages and lymph node metastases. |
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