Ag-mediated Tandem Radical Addition/Cyclization Reaction Of N-arylacrylamides With Acetonitrile

3,3-Disubstituted oxindoles are an important family of biologically active heterocycles,and found in nature products.Over past decades,numerous synthetic methodologies have been developed for their synthesis.Recently,the tandem radical cyclization of N-arylacrylamides has provided a new powerful approach to access various diversely functionalized 3,3-disubstituted oxindoles.Obviously,these protocols are also of great potential in the field of oxindole-based drug discovery and structural library design.Hence,we summarized the research progress.The review will highlight recent advances in this field as well as applications in natural product synthesis in terms of different types of radical source,further forecasting remarkable research area and the potential of this novel.We also resume the challenges that still remain for the future research.Though the review,we found that there were many limitations of the transition-metal catalytic during decarboxylative coupling procedure to synthesize the3,3-disubstituted oxindoles derivatives.On this account,we reported a highly efficient and practical approach for the synthesis of 3,3-disubstituted oxindoles through AgOAc-mediated radical cyanomethylation.The reaction conditions employed in the protocol exhibiting a wide range of functional groups compatibility.This work illustrates the example of Ag(I)-mediated C(sp~3)-H bond functionalization to construct C-C bonds in the synthesis of 3,3-disubstituted oxindoles.