| Background Diverticulosis comprises various entities related to the presence of diverticula of the colon,referring to herniations through weak site of the bowel wall resulting a bulging of pouches.The prevalence and distribution of diverticulosis are highly heterogeneous,on account of the ethnic and geographical variability.which is rare in Asia,while is common in western countries.A rising incidence of diverticulosis is a common Phenomenon condition worldwide.However,The pathogenesis of diverticulosis is unknown.limited data regarding to risk factors and endoscopic characteristics of diverticula are available until now.We aimed to evaluate that the our study population.Aim(1)determine trends in diverticulosis over the past half decade owing to data scarcity from Tianjin(2)evaluate the number,size,depth and location of colon diverticula in our study population.(3)investigate sex differences in individual risk factor in Tianjin Method(1)Study: A total of 26,463 colonoscopies performed between January 2011 and December 2015 were reviewed respectively at the endoscopy center of Tianjin Medical University General Hospita.The trends in diverticulosis were analyzed in terms of age growth and year increase.Additionally,associations of the occurrence of diverticula with age(39,40-59,and 60 years)and gender were determined using a logistic regression model.(2)We collected data from patients who underwent colonoscopy at the endoscopy centerl from January 2016 to September 2017.Any Some colon diverticula was carefully assessed and recorded in our electronic database according to endoscopic findings.Associations between participant characteristics and diverticula were determined by using logistic regression model.(3)Patients with colonic diverticulosis who underwent indicated colonoscopy were queried with respect to medical history and demographic features from january 2016 to August2016.Demographic information,life style factors and co-morbidities were retrieved from a prospective dataset.Multiple regression analyses were performed to determine precipitating factors of diverticula.Results(1)Results: One thousand and forty five colonic diverticulosis were identified from january 2016 to August 2016,with an overall prevalence of 3.8%.A preponderance of right-sided diverticulosis were demonstrated,accounting for 72.9% of included subjects.The proportion of colonic diverticulosis increased significantly(P<0.001 for trend)from 2.78%(112/4028)in 2011 to 4.98%(309/6208)in 2015.The proportion of patients of all age groups with diverticulosis increased significantly(P<0.001 for trend)in correlation with year increase.There was a greater proportion of diverticulosis,regardless of the distribution,in patients aged 60 than other younger age groups(P<0.001 for trend).Multivariate analysis showed older age and male gender were independent risk factor for the incidence of diverticulosis.(2)A total of6742 applicable records were retrieved from our colonoscopy database,with 401participants(5.9%)present with one or more diverticulosis.Patients with diverticula(mean age: 59)were significantly older and showed male preponderance than those without diverticula.Right-sided,left-sided and bilateral diverticulosis were found in296(73.8%),50(12.5%)and 55 cases(13.7%),respectively.The patients with right-sided diverticula(mean age: 51.5)were younger than those with left-sided diverticula(mean age: 64,P< 0.05)which were frequently in female(P= 0.048).Participants represented both-sides had an increased odds caused of having a greater burden(OR: 37.15,95% CI: 11.23-122.88,P < 0.001)or deep diverticula(OR: 3.38,95% CI: 1.08-10.53,P =0.036).(3)we quried patients who underwent indicated colonoscopy from january 2016 to August 2016 Of 4,386 enrolled patients,colonic diverticulosis were detected in 218 cases(4.97%).Multiple logistic regression analysis implicated increasing age(P<0.001),red meat 100g/d(P<0.001),smoking(P=0.035),rheumatologic diseases(P=0.035)and NSAIDs(P=0.020)were significantly associated with diverticulosis in men,whilst advancing age(P=0.013),BMI(P=0.001),smoking(P<0.001),rheumatologic diseases(P<0.001),hypertension(P=0.047),colonic polyps(P<0.001)and antihypertensive medications(P<0.001)in women.Conclusions(1)Colonic diverticulosis has been increasing in Northern China,where a rapid agingand urbanization is ongoing.This trend may impose a suffering problem and exert Heavy burdens on the healthcare system and society in the near future,which warrants further investigation and intervention.(2)The colonic diverticula were predominantly right-sided,male,and older age in mainland China.Of these,patients with right-sided diverticula were younger than those with left-sided ones.The emergence of crowed and deep diverticula was more likely observed in the individuals with bilateral distributed pattern.(3)It is pivotal to take account of differentially sex-related factors in regard to the development of uncomplicated colonic diverticulosis. |
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