The Progress Of The Study On Ph-like Acute Lymphoblastic Leukemia

Ph-like acute lymphoblastic leukemia is a high-risk subtype of B cell precursor ALL,which represent high aggressive and lead to poor prognosis.It has a characteristic gene mutation in children and adults.There is no definite diagnostic standard,It is currently mainly based on gene expression analysis.It is characterized by a gene-expression profile similar to BCR-ABL,without BCR-ABL fusion gene.It occurs more often in male individuals and patients with Down syndrome.It is associated with age,approximately 12% in children,21% in adolescents(16-20 years of age),and 20% to 24% in adults older than 40 years,with a peak(27%)in young adults 21 to 39 years old.It is associated with minimal residual disease(MRD).Strict monitoring of MRD level is of great significance for guiding the treatment of the disease and prognosis risk assessment.Tyrosine kinase inhibitors(TKIs)provide the road and hope for this disease.This article provides an overview of the Ph-like acute lymphoblastic leukemia.