Clinical Therapeutic Effect Of Jieyu Decoction Plus Or Minus Combined With Paroxetine In The Treatment Of Liver Qi Stagnation Type Depression Syndrome

Objective: To observe the clinical effect of Jieyu decoction plus or minus combined with Paroxetine in the treatment of liver qi stagnation type depression syndrome,and to study its effect on Hamilton Depression Scale(HAMD)score 、 Traditional Chinese Medicine symptom(TCM)score,Self-rating Depression Scale(SDS)score、Treatment Emergent Symptom Scale(TESS)score.To explore the intervention mechanism of Jieyu prescription on patients with stagnation of liver and qi,and to provide a new idea for the treatment of depression by integrated Chinese and western medicine.Method: From September 2016 to SePtember 2017,patients with depression were selected from insomnia clinic of Hebei Provincial traditional Chinese Medicine Hospital.50 patients who met the inclusion criteria were selected as the study objects.According to the random digital table method,the patients were divided into treatment group and control group,25 patients in each group.The age,sex and course of disease of the two groups were analyzed by SPSS 21.0(P>0.05).The difference was not statistically significant and comparable.Both groups were treated with western medicine Paroxetine while the Jieyu decoction plus or minus was additionally used in oral way for the treatment group.To observe the changes of HAMD score、TCM symptom score、SDS score and Tess score before and after treatment.The clinical efficacy and safety of the two groups were evaluated.Results:1.Comparison of baseline data: There was no significant difference in sex,age and course of disease between the two groups(P>0.05).2.Comparison of Hamilton Depression scale score between the two groups before and after treatmentWith the prolongation of the treatment time,the HAMD score of the treatment group and the control group decreased continuously.There was no significant difference between the two groups before and 2 weeks after treatment(P>0.05),4 and 8 weeks after treatment.The scores in the treatment group were lower than those in the control group(P<0.05).After 8 weeks,the overall curative effect of the two groups was significantly lower than that of the control group(P<0.05).The therapeutic effect of treatment group was better than that of control group.3.Comparison of the changes of TCM symptom score before and after treatment between the two groupsThe longer the treatment time between the treatment group and the control group,the lower the score was(P<0.05).There was no significant difference between the two groups before treatment and 2 weeks after treatment(P>0.05),4 weeks and 8 weeks after treatment.The scores in the treatment group were lower than those in the control group(P<0.05).After 8 weeks,there was significant difference in the overall curative effect between the two groups.The therapeutic effect of the treatment group was better than that of the control group.4.Comparison of the changes of self rating Depression scale scores between the two groups before and after treatmentThe SDS scores of the two groups decreased after treatment,The difference between treatment group and pre-treatment group was statistically significant(t=21.429,P<0.001),the difference of control group was statistically significant(P<0.001),After treatment,the difference between the treatment group and the control group was statistically significant,the score of the treatment group was lower than that of the control group(P<0.001).The effect of the treatment group was better than that of the control group.5.Comparison of Treatment Emergent Symptom Scale scores before and after treatment between the two groupsThere was no significant difference in TESS scores between the two groups before treatment,but after treatment the scores in the treatment group were lower than those in the control group(P<0.001).There was no difference in side effects before and after treatment in the treatment group.The scores of the control group after treatment were higher than those before treatment(P<0.001).The side effects such as dry mouth and nausea were not treated in the treatment group,then disappeared,indicating that the treatment of liver stagnation qi stagnation type of treatment,the treatment group is more safe.Conclusions:1.The treatment of Jieyu decoction combined with Paroxetine can significantly improve the clinical symptoms of patients with stagnation of liver qi,the Hamilton Depression Scale(HAMD)score,TCM symptom score and self rating Depression Scale(SDS)score in the treatment group decreased significantly compared with those before treatment,and the effect of the treatment group was also better than that in the control group.2.The effect of Jieyu decoction plus or minus combined with Paroxetine in the treatment of liver qi stagnation type depression syndrome is better than that of Paroxetine alone,and it is worth popularizing.