Relationship Between Serum Uric Acid,serum Bilirubin And Carotid Atherosclerosis In Type 2 Diabetic Patients

Objective:To investigate the relationship between serum uric acid(SUA),serum bilirubin(BIL)and type 2 diabetes mellitus(T2DM)patients with carotid atherosclerosis(CAS).To investigate the pathogenesis of carotid atherosclerosis in SUA,BIL and T2 DM patients.Methods:The type 2 diabetes patients who were hospitalized in the Department of Neurology,Affiliated Hospital of Chengde Medical College from March to September 2017 were selected and screened in strict accordance with the inclusion criteria and exclusion criteria.A total of 100 patients were selected.All subjects enrolled in the study were carotid ultrasound examinations performed by professional staff,and carotid intima-media thickness(IMT)data were recorded and mean IMT thickness was calculated.According to the results,there were 48 non-CAS groups and 52 CAS groups.Recorded in detail the subject’s gender,age,height,body weights,moking history,drinking history and baseline systolic blood pressure(SBP),baseline diastolic blood pressure(Diastolic blood pressure,DBP)and other basic information,and statistical research object test results: uric acid(UA),Homocysteine(HCY),Total cholesterol(TC),Low density lipoprotein(LDL),High density lipoprotein(HDL),Clinical data such as Direct bilirubin(DBIL)and Indirect bilirubin(IBIL).SPSS19.0 software was used for statistical analysis.The continuity data were tested for normal distribution,with normal distribution of measurement data to indicate that the comparison between groups was performed using independent sample t-tests.Count data using the composition ratio,the comparison between groups using 2 tests.Analysis of risk factors and protective factors by factorial analysis using multivariate Logistic regression analysis.P<0.05 considered the difference statistically significant..Results:1.Comparison of data between the two groups: Body mass index,total cholesterol,low-density lipoprotein,uric acid,homocysteine,and baseline systolic blood pressure were higher in the carotid atherosclerosis group than in the non-carotid artery atherosclerosis group(P< 0.05),the difference was statistically significant;total bilirubin,direct bilirubin,and indirect bilirubin were lower in the carotid atherosclerosis group than in the non-atherosclerosis group(P<0.05),and the difference was statistically significant.There was no significant difference between the other two groups(P>0.05).2.Multivariate Logistic regression analysis of the above factors showed that uric acid,body mass index and homocysteine were risk factors for CAS(P<0.05),while IBIL level was a protective factor for CAS(P<0.05).Conclusion:Serum uric acid and serum bilirubin were significantly associated with the formation and development of carotid atherosclerosis in patients with type 2 diabetes.High levels of uric acid are independent risk factors for carotid atherosclerosis,and BIL is a protective factor against the formation of anti-CAS.