Value Of B Type Natriuretic Peptide In The Prediction Of Hemodynamically Significant Patent Ductus In Premature Infants

The arterial catheter is part of the fetal circulation and is connected to the descending of the aortic arch and the pulmonary artery bifurcation near the left pulmonary artery.Under normal circumstances,most term newborns are functionally closed 10-15 hours after birth.Preterm infants have arterial catheters.The immature wall development and the failure to promptly close the patent ductus arteriosus after birth are associated with an increase in birth weight and birth gestational age.The patent ductus arteriosus has been a research hotspot in the field of premature infants’ medical science.The definition of hsPDA currently used more often is: the presence of arterial catheter by echocardiography,and there are corresponding clinical symptoms,such as heart murmurs,tachycardia,and so on.The presence of hsPDA on the one hand leads to an increase in blood volume in the pulmonary circulation,and on the other hand leads to the performance of systemic blood ischemia,which aggravates dyspnea,causes intracerebral hemorrhage,hypotension,necrotizing enterocolitis,and shock.B-type natriuretic peptide is a hormone secreted by ventricles when the volume is overloaded.Recent studies have shown that B-type natriuretic peptide as a biomarker can be used to predict and diagnose patent ductus arteriosus,however domestic and foreign scholars There is no unified conclusion at present,limiting its application in the area of premature babies.This study investigated the relationship between B-type natriuretic peptide levels and patent ductus arteriosus in early postnatal gestational age ≤ 32 weeks of preterm infants and explored its predictive value.Objective:To investigate the diagnostic value of B-type natriuretic peptide(BNP,B-type natriuretic peptide)in haemodynamicaly significant patent ductus(hsPDA)with significant hemodynamic changes in preterm infants.Methods:From September 2016 to September 2017,the preterm infants admitted to the Department of Neonatology,Affiliated Hospital of Chengde Medical College were selected as the study subjects.Among them,19 patients with patent ductus arteriosus who had significant changes in hemodynamics and no hemodynamic changes were observed.56 cases of patent ductus patula(nhsPDA)and 56 cases of non-arterial catheter(nPDA)were used as control group.The relevant data of the children were collected,combined with echocardiography to detect the heart condition of the children and determine the B-type benefits of 1,3,and 7 days after birth.Sodium peptide values and statistical analysis.The value of the B-type natriuretic peptide in the diagnosis of patent ductus arteriosus in preterm infants was analyzed by the receiver operating characteristic curve(ROC curve).Results:1.Plasma levels of B-type natriuretic peptides were statistically significant between nPDA and PDA,nhsPDA and hsPDA.2.In the diagnosis of hsPDA,the level of B-type natriuretic peptide was the highest on the third day after birth,with an area under the ROC curve of 0.964,a sensitivity of 1,and a specificity of 0.75.Conclusion:B-type natriuretic peptide levels on the third day after birth in preterm infants can be used to predict the risk of haemodynamicly significant patent ductus arteriosus and have the highest diagnostic value.