| Objective To analysis the efficacy and safety of paliperidone in the treatment of schizophrenia.To observed the effect of clinical treatment on serum prolactin and glucose and lipid metabolism in patients.To summarized the clinical reasonable dosage of paliperidone.Methods 120 schizophrenic patients admitted to our hospital from January 2016 to October were selected as the subjects of this study.Patients were randomly divided into control group and observation group with 60 cases in each group.Patients in the control group were treated with risperidone,while the observation group was treated with paliperidone.The positive and negative symptom scale(PANSS),the clinical efficacy scale(CGI),SAPS and SANS were used to evaluate the patients of two groups before and after treatment.The clinical curative effect and the incidence of adverse reactions after treatment were observed.The serum prolactin and lipid metabolism index test were carried out.The blood concentration of the patients in the observation group was detected to determine the reasonable dosage of paliperidone.Results The PANSS score of the observation group was significantly lower than that of the control group at 1 weeks,2 weeks,4 weeks and 8 weeks after treatment,with statistical significance,respectively are(64.2±11.7),(56.3±9.8),(53.6±9.5),(46.8±8.4).The SAPS score of the observation group was significantly lower than that of the control group at 1 weeks,2 weeks,4 weeks and 8 weeks after treatment,with statistical significance,respectively are(13.5±3.1),(11.2±3.1),(10.3±2.5),(8.6±1.9).The SANS score of the observation group was significantly lower than that of the control group at 1 weeks,2 weeks,4 weeks and 8 weeks after treatment,with statistical significance,respectively are(17.5±6.5),(14.6±5.2),(14.5±4.7),(13.2±4.7).The CGI score of the observation group was significantly lower than that of the control group at 1 weeks,2 weeks,4 weeks and 8 weeks after treatment,with statistical significance respectively are(3.5±0.7),(3.2±0.6),(2.9±0.6),(2.1±0.7).The clinical effective rate of the observation group was 86.7%,which was significantly higher than that of the control group(P=0.049).There was no significant difference in the incidence rate of adverse drug reactions between dizziness,weakness,drowsiness,insomnia,blurred vision and tachycardia in the two groups(P=0.800).The serum prolactin,fasting blood glucose,triglyceride and high density lipoprotein cholesterol in the observation group were significantly higher than those in the control group,The serum prolactin respectively are(36.4±18.2)μg/L,(35.7±17.9)μg/L,(35.8±17.5)μg/L,fasting blood glucose are(5.1±1.2)mmol/L,triglyceride is(1.5±0.3)mmol/L.Patients who were significantly lower than risperidone.But,there was no significant difference between the two groups in postprandial 2H blood glucose,total cholesterol,high density lipoprotein,low density lipoprotein,apolipoprotein A1 and apolipoprotein B(P >0.05).The dosage was increased and the blood drug concentration continued to rise with the prolongation of medication time,there was a positive correlation between the dosage and the drug concentration.The rational dose of Paliperidone Extended-Release Tablets is 5.3mg--13.7 mg/ days.Conclusion Paley’s treatment of schizophrenia can improve the psychiatric symptoms,have higher medication safety,and less influence on serum prolactin,blood glucose and blood lipid.There is a positive correlation between the serum concentration and the dosage of the drug.The rational dose of Paliperidone Extended-Release Tablets is 5.3mg-13.7mg/ days. |
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