Effect Of Family History Of Hypertension On Serum Metabolism Indexes And Carotid IMT Of Normal High Blood Pressure

Objectives Disscuss the influence of normal high blood pressure with family history of hypertension on metabolic indexes and carotid intima-media thickness(IMT)Methods Selected for the period from June 2016 to June 2017,a total of 1556 health examiners from the physical examination Center of the 266th Hospital of the Chinese people’s Liberation Army were selected as the subjects of the study,to investigate age,family history,past illness,smoking,alcohol consumption,standardized measurements of height,weight and blood pressure,according to the inclusion and exclusion criteria,screening out the normal high blood pressure population,that is,people whose systolic blood pressure of 120-139mmHg and/or diastolic blood pressure of 80-89mmHg,a total of 480;.According to whether there is a family history of hypertension,group A:normal high blood pressure population with family history of hypertension,a total of 254,of these,132 were for men and 122 for women;and based on the presence of hyperlipemia,People with normal high blood pressure and hyperlipemia with a family history of hypertension were assigned to group A1,(135).Based on the presence of diabetes,the normal high blood pressure associated with diabetes mellitus with family history of hypertension was assigned to A2 group(120).group B:no hypertension family history normal high blood pressure population,a total of 226,of these,138 were for men and 88 for women;And based on the presence of hyperlipemia,People with normal high blood pressure and hyperlipemia without a family history of hypertension were assigned to group B1,(105).Based on the presence of diabetes,the normal high blood pressure associated with diabetes mellitus without family history of hypertension was assigned to group B2,(96).Serum metabolic indicators for all population groups include:cholesterol(CHO),low density lipoprotein cholesterol(LDL-C),homocysteine(HCY),uric acid(UA),the intimamedia thickness of carotid artery was measured by carotid ultrasound.Serum metabolic indexes and carotid IMT were compared between the groups.Using SPSS21.0 software for statistical analysis,P<0.05 had statistical significance.Results 1 The sex,age,body mass index,hyperlipidemia,diabetes mellitus and smokers in patients with normal high blood pressure with a family history of hypertension(group A),compared with normal high blood pressure without family history of hypertension(group B),there were no significant statistical difference(P>0.05).2 The levels of cholesterol,low density lipoprotein cholesterol(LDL-C),homocysteine(HCY),and serum uric acid(UA)in patients with normal high blood pressure with a family history of hypertension(group A),compared with normal high blood pressure without family history of hypertension(group B),there were significant statistical difference(P<0.001).3Normal high blood pressure with family history of hypertension(group A)carotid intimamedia thickness(IMT),compared with normal high blood pressure without family history of hypertension(group B),there was statistical difference(P<0.05).4 Normal high blood pressure people with family history of hypertension(group A),men compared to women,the level of serum low density lipoprotein cholesterol(LDL-C)and uric acid(UA),there were significantly different(P<0.05),and cholesterol,homocysteine(HCY)and carotid intima-media thickness(IMT),there were no statistical difference(P>0.05).5 Normal high blood pressure group without family history of hypertension(group B),men compared to women,the level of serum uric acid(UA),there was significantly different(P<0.05),and cholesterol,low density lipoprotein cholesterol(LDL-C),homocysteine(HCY)and carotid intima-media thickness(IMT),there were no statistical difference(P>0.05).6 Normal high blood pressure with hyperlipemia with family history of hypertension(group A1)was compared with that with normal high blood pressure with hyperlipemia without family history of hypertension(group B1),the levels of cholesterol(CHO),low density lipoprotein cholesterol(LDL-C),homocysteine(HCY),uric acid(UA)and carotid IMT,there were significantly different(P<0.001).7 Normal high blood pressure with diabetes with family history of hypertension(group A2)was compared with that with normal high blood pressure with hyperlipidemia without family history of diabetes(groupB2),the levels of cholesterol(CHO),low density lipoprotein cholesterol(LDL-C),homocysteine(HCY),uric acid(UA)and carotid IMT,there were significantly different(P<0.05).8 Family history of hypertension,diabetes,and age were risk factors for carotid IMT thickening in people with normal high blood pressure(P<0.05).After controlling for hyperlipidemia,sex and smoking,people with normal high blood pressure with a family history of hypertension are at risk of carotid IMT thickening,it is 6.405 times higher than the normal high blood pressure group without family history of hypertension,(OR 6.405,95%CI 4.157~9.867);The risk of carotid artery IMT thickening is high among people with diabetes and normal high blood pressure,it is 1.913times the normal high blood pressure group without diabetes,(OR 1.913,95%CI1.113~3.286);For every increase in age by one year,the risk of carotid IMT thickening increases by 97.1%,(OR值为1.971,95%CI 1.618~2.401).Conclusions 1 The family history of hypertension has an effect on the serum metabolic indexes,including cholesterol,low density lipoprotein cholesterol,homocysteine and uric acid in normal high blood pressure population.2 Effects of family history of hypertension on low density lipoprotein cholesterol(LDL-C)and uric acid(UA)levels in men with normal high blood pressure are different from those in women.3 The family history of hypertension has an effect on carotid artery intima-media thickness in normal high blood pressure group.4 Family history of hypertension may increase the risk of carotid intimamedia thickness thickening in people with normal high blood pressure.