Correlation Between Serum Uric Acid Level And Diabetic Retinopathy In Type 2 Diabetic Patients

Background: diabetes(diabetes mellitus,DM)is a common metabolic disease,clinical to elevated blood sugar as the main characteristics of chronic persistent,can cause heart,eyes,kidney,nerve and vascular tissues and organs damage.According to the secretion of insulin,it was divided into type 1 diabetes(T1D M)and type 2 diabetes(T2D M).In recent years,with the rapid development of our country’s economy,residents living standards improve,a great change of the way of life,increasing diabetes prevalence in successive years in China,according to the latest figures,in our country residents over the age of 20,type 2 diabetes has reached 92.4 million.According to epidemiology,diabetes has been ranked among the three major chronic non-communicable diseases of human health in the 21 st century,followed by cancer and cardiovascular disease.Long-term hyperglycemia can lead to pathological changes of tissues and organs in the patient’s body,and subsequently,acute and chronic complications arise.Blood vessels and,in particular,not only affects the great vessels of heart head blood-vessel,also affects to the kidneys,the small blood vessels in the retina,basically have Diabetic nephropathy(DiabeticNephropathy,DN),Diabetic Retinopathy,Diabetic Retinopathy,DR).Diabetic retinopathy is a more common complication,which seriously threatens the patients’ physical and mental health and quality of life,which can lead to blindness if not treated promptly.This phenomenon and the incidence of type 2 diabetes rising accordingly,represented by diabetic retinopathy of the incidence of the chronic complications of diabetes are also constantly increased,therefore,clinical prevention and treatment of complications is particularly important.Current clinical commonly used detection of blood sugar control degree and the degree of metabolic abnormalities indicators are glycosylated hemoglobin(Hb)A1c and fasting plasma glucose(FPG),the application of these two kinds of indexes in the treatment of diabetes and the prevention and treatment of complications of plays an important role.Not only that,the American diabetes association(ADA)in the diagnosis of diabetes guidelines made 2010 updates,officially become one of the diagnostic indicators of diabetes HbA1 c,and have the same diagnostic value of blood sugar,and suggests that people with diabetes(non pregnancy)should be the HbA1 c control blood sugar in less than 7%.Uric Acid(UA)is the final product of the oxidative decomposition of purine nucleotide.There are two main sources.80% of them are endogenous uric acid,which is obtained from the oxidation of purine nucleotide.The other 20 percent are exogenous uric acid,which is mainly produced by ingesting animal protein or other foods containing purines.In order to maintain the normal range of uric acid in the human body,it is necessary to ensure that the production of uric acid is in a dynamic balance with the discharge volume,and on the other hand,it also protects the body cells.However,when the patient’s body of purine content more than normal,the balance of the steady state will be broken,the higher the concentration of blood uric acid will follow,especially for the blood uric acid in the body after a large number of accumulation,in large part will induce high uric acid hematic disease.The standard of clinical definition of hyperuricemia is: male blood uric acid is greater than 420umol/L;The female menopause was above 360umol/L and 420umol/L respectively.If the body is chronically in hyperuricemia,uric acid will form the crystal of uric acid in the body,which can be deposited in the islet B cells,thus destroying the islet B cells.If the patient has a basic disease of diabetes,damaged islet B cells can lead to decreased insulin secretion,which can further aggravate the condition of diabetes.Objective: to investigate the correlation between serum uric acid level and severity of diabetic retinopathy in type 2 diabetic patients.Selection methods: between January 2014 and January 2017 in xiangxi autonomous prefecture people’s hospital of 500 patients with type 2 diabetes,conforms to the 1999 world health organization(who)standards of diabetes,in the following a diagnosis of type 2 diabetes or diabetic retinopathy.Records the general situation of the patient,ages 30 to 60 years,the female menopause and the nonmenopause.1.The experiment was divided into male and postmenopausal women and unmenopausal women.2.Stratified the study subjects according to uric acid level,and calculated the incidence of diabetic retinopathy in each layer,and analyzed the relationship between serum uric acid level and retinopathy.3.The study subjects were divided into female postmenopausal patients and non-menopausal patients,and analyzed the differences in the incidence of diabetic retinopathy in the level of blood uric acid.Statistical software SPSS19.0 statistical software was used to calculate and analyze the data,and the difference was statistically significant in P < 0.05.To investigate the correlation between serum uric acid level and retinopathy in type 2 diabetic patients;The incidence of retinopathy in type 2 diabetic patients.Results: 1.The severity of retinopathy in type 2 diabetic patients is aggravated with the increase of serum uric acid level.2.he incidence of diabetic retinopathy increased significantly in male and postmenopausal women with type 2 diabetes and the level of serum uric acid between 416-519mmol/L.3.There is no significant difference in the incidence of diabetic retinopathy between menopausal women and non menopausal women with type 2 diabetes mellitus.4.The incidence of diabetic retinopathy in type 2 diabetes with hyperuricemia is higher than that in patients without hyperuricemia.Conclusion: 1.there is a certain correlation between serum uric acid level and severity of diabetic retinopathy in patients with type 2 diabetes.The severity of retinopathy aggravated with the increase of serum uric acid level.2.The incidence of diabetic retinopathy is significantly higher in patients with type 2 diabetes and men and postmenopausal women whose serum uric acid level is between 416-519mmol/L.3.The incidence of diabetic retinopathy in type 2 diabetes with hyperuricemia is higher than that in patients with non hyperuricemia.4.There is no significant difference in the incidence of diabetic retinopathy between menopausal women and non menopausal women with type 2 diabetes mellitus.