A Comparative Study Of Event-related Potential Contingent Negative Variation In First Episode Schizophrenia

Objective: To explore the differences in event-related potential CNV between the firstepisode schizophrenia group and the normal control group,and analyze the correlation between CNV amplitude and behavioral data and cognitive function and psychiatric symptoms.Methods: A total of 42 resident patients with first-episode schizophrenia were admitted to the Second Affiliated Hospital of Jining Medical College from June 2017 to February2018.30 healthy people were enrolled as controls.The MATRICS consensus cognitive battery(MCCB)was used to evaluate the cognitive areas of information processing speed,the ability to pay attention / alertness of the two groups,the patients were assessed psychotic symptoms with the Positive and Negative Syndrome Scale(PANSS).The stimuli were underlearned Braille font dot patterns,which were presented in pairs(cue-probe).We imported all data into EXCEL and built a database,and used the SPSS22.0 for statistical processing.Results: 1.The study group and control group: EBX-AY in first-episode schizophrenia group was significantly higher than that in normal group(P < 0.05);the CNVB amplitude in study group was significantly lower(in the negative direction)than that in normal group(P<0.05);and the CNVB-A amplitude was significantly higher than that in normal group(P<0.05).There were significant differences in the scores of trail making test,symbol coding test,category fluency test and continuous performance test between the two groups.2.There was no significant difference in first-episode schizophrenia group between CNVA amplitude and CNVB amplitude(P>0.05).CNVA amplitude was significantly higher than CNVB amplitude in the normal control group(P<0.05)。 3.In first-episode schizophrenia group,there was a positive correlation between EAY、EBX andage,EAY was negatively correlated with years of educated,and EBX-AY was negatively correlated with the positive symptom score and the PANSS score of the patients.In the normal control group,there was a negative correlation between EAY and years of educated,EBX and EBX-AY were positively correlated with the score of CPT2 and CPT mean.4.In firstepisode schizophrenia group,there was a negative correlation between CNVA amplitude and the score of CPT1、CPT2、CPT mean and symbol coding test(for CP3,r=-0.333,r=-0.364,r=-0.375,r=-0.312,all P<0.05),CNVB amplitude was negatively correlated with the score of CPT2、CPT mean and symbol coding test(for CP3,r=-0.429,r=-0.323,r=-0.442,all P<0.05).CNVB amplitude was negatively correlated with the score of CPT3(for CP3,r=-0.342,P<0.05).In the normal control group,there was a negative correlation between CNVB-A amplitude and the score of category fluency test(for CP3,r=-0.629,P<0.05),CNVB-A amplitude was positively correlated with the score of CPT2(for CPz,r=0.366,P<0.05).5.At the CP3 electrode,the EBX 、 EBX-AY consistently showed significant associations with the amplitude of the CNVB and CNVB-A(r=-0.531,r=-0.487,r=-0.431,r=-0.369,all P<0.05)in normal control group.Conclusion:1.There was an impaired capability of goal maintenance in First-episode schizophrenia.2.The CNVB amplitude in study group was significantly lower(in the negative direction)than that in normal group,the difference between CNVB amplitude and CNVA amplitude in the first-episode schizophrenia group was significantly less than that in the normal control group.3.There were more obvious defects in the cognitive areas of information processing speed and the ability to pay attention / alertness in first-episode schizophrenia.4.The impairment of the ability to pay attention / alertness and the information processing speed was linked to lower CNVA and CNVB(in the negative direction)in first-episode schizophrenia.