Randomized Controlled And Clinical Research On The Treatment Of Liver And Spleen From Chronic Superficial Gastritis

ObjectiveThe treatment according to syndrome differentiation is the essence and characteristic of Traditional Chinese Medicine(TCM).In clinical,treating the same disease with different methods,and treating the different disease with the same methods are the important embodiment of the spirit of the treatment according to syndrome differentiation.In this study,we aim to carry out a randomized cross-control study of two therapeutic prescriptions,namely dispersing stagnated liver qi for regulating stomach and regulating the flow of vital energy and remove obstruction toit for liver-stomach disharmony and deficiency-weakness of spleen-qi in chronic superficial gastritis,so as to explores the law of the application of TCM in CSG,and tries to demonstrate the scientificity and importance of the treatment of syndrome differentiation from multiple angles.MethodsThe patients were diagnosed in the outpatient of the spleen and stomach department in the first affiliated hospital of Guangzhou university of traditional Chinese medicine from June 2017 to February 2018 as chronic superficial gastritis of liver-stomach disharmony and deficiency-weakness of spleen-qi.The patients who meet the criteria were randomly assigned to the dispersing stagnated liver qi for regulating stomach group(A group)and regulating the flow of vital energy and remove obstruction toit group(B group)using the random number table method.After 4 weeks of observation,the four-diagnosis registration form was used for registration before treatment,after treatment for 2 weeks,4 weeks of data,respectively.The patients in the first 2 weeks of good curative effect continued the original treatment to 4 weeks,and for the patients with poor efficacy,re-differentiation of symptoms and signs was performed.The corresponding prescriptions were adjusted according to the specific syndrome type and continued to be treated for 4 weeks,and the curative effect was evaluated.The Powder for Regulating Liver and Spleen was used for flavor in the A group,and Jiawei Xiangsha Liujunzi decoction was used for flavor in the B group.The administration should be one dose for a day,flip slag and fry again,and take for twice after a meal.ResultsA total of 50 cases of chronic superficial gastritis were diagnosed in this study in the outpatient of the spleen and stomach department the first affiliated hospital of Guangzhou university of traditional Chinese medicine from June 2017 to February 2018.There were 26 cases in the A group,of which 13 cases were liver-stomach disharmony type,and 13 cases of spleen and stomach qi deficiency type.There were 24 cases in the B group,of which 13 cases were spleen and stomach qi deficiency type,and 11 cases were liver-stomach disharmony type.No significant difference was found in gender,age(year)and course of disease(week)(all P > 0.05).The gender and age distribution of the cases were basically consistent with the epidemiological strip survey of chronic superficial gastritis in China.Therefore,the cases included in this study were representative.No significant difference was found in Liver and Spleen in liver-stomach disharmony type 、spleen and stomach qi deficiency type(P>0.05).For the patients in liver-stomach disharmony type,the main symptoms were epigastric distension and depression,epigastric pain,belching hiccup,impetuous disposition,stabbing hypochondrium pain,and dry and bitter taste before treatment;after treatment,the symptoms were obviously improved and the curative effect was remarkable(P < 0.01).The efficacy of Xiangsha Liujunzi decoction in liver-stomach disharmony type was poor than in spleen and stomach qi deficiency type(P < 0.05).For the patients in spleen and stomach qi deficiency type,the main symptoms were epigastric pain,poor appetite,coldness of the body and limbs,and tastelessness before treatment;after treatment,the symptoms were obviously improved and the curative effect was remarkable(P < 0.01).ConclusionThe Powder for Regulating Liver and Spleen and Xiangsha Liujunzi decoction both have significant efficacy in the treatment of liver-stomach disharmony type and spleen and stomach qi deficiency type in patients with chronic superficial gastritis.Additionally,the correct treatment of syndrome differentiation has obvious effect on the treatment of chronic superficial gastritis,and it shows the scientificalness and importance of the correct syndrome differentiation in clinical.Finally,liver and spleen is related to each other,and it is feasible and rational for the liver and spleen in the treatment of chronic superficial gastritis.