The Rule Of Syndrome And Treatment In Stage Ⅲ And Ⅳ Of Diabetic Nephropathy And A Summary Of Professor Wang Xiaoguang’s Experience

Objective:Through clinical data analysis,the relationship between glucose metabolism disorder,oxidative stress response,inflammatory reaction,lipid metabolism disorder and diabetic nephropathy and blood glucose control was investigated.At the same time,further study on traditional Chinese governance law and patients with DN,sugar metabolic disorder,oxidative stress,inflammation and lipid metabolism disorder,the relationship between TCM syndrome differentiation and treatment for DN provide certain theoretical basis.In addition,further Ⅲ,Ⅳ period through inducing diabetes nephrosis patient’s disease,symptoms,medication,and so on and so forth,to summarize tutor’s clinical experience in the treatment of Ⅲ,Ⅳ stage of diabetic nephropathy.Methods:112 patients who were diagnosed in accordance with stage IV of stage Ⅲdiabetic nephropathy and presented with deficiency of spleen and kidney qi or yin deficiency of liver and kidney,and two types of syndrome of blood stasis or phlegm turbidity,were diagnosed by the Department of CLIFFORD of Guangzhou University of traditional Chinese Medicine and outpatient department of Department of Nephrology,Guangzhou University of traditional Chinese Medicine.As an object of study,The data were set up by Microsoft Office Excel and analyzed by SPSS17.0 software.Through clinical data analysis,the progress of glucose metabolism disorder,oxidative stress reaction,inflammatory reaction,lipid metabolism disorder and diabetic nephropathy were explored.The relationship between blood glucose control levels.At the same time,the relationship between TCM syndrome and treatment and glucose metabolism disorder,oxidative stress,inflammatory reaction and lipid metabolism disorder in DN patients was further studied.Results:1.The level of AGE in patients with stage Ⅳ DN was significantly higher than that in patients with stage Ⅲ(P < 0.05),and the level of IL-6 in patients with stage Ⅳ DN was significantly lower than that in patients with stage Ⅲ(P < 0.05).There was no significant difference in TG levels between stage Ⅲ group and stage Ⅳ group(P > 0.05).2.Compared with the blood glucose control group,the level of AGEN IL-6was significantly higher in the blood glucose control substandard group than that in the blood glucose control standard group(P < 0.05),but there was no significant difference between the blood glucose control group and the blood glucose control standard group in SOD level(P >0.05),and in the blood glucose control substandard group,there was no significant difference(P >0.05).In the blood glucose control group,the level of TG was significantly lower than that in the control group(P <0.05).3.Compared with the deficiency of spleen and kidney qi,the level of AGE and IL-6 was significantly higher in patients with liver and kidney Yin deficiency syndrome(P <0.05).Compared with the deficiency of spleen and kidney qi,SOD level was significantly lower in patients with liver and kidney Yin deficiency syndrome(P < 0.05).Compared with the deficiency of spleen and kidney qi,there was no significant difference between TC and TG level in patients with liver and kidney Yin deficiency syndrome(P >0.05).4.There was no significant difference in AGE,SOD and il-6 levels in blood stasis syndrome(P > 0.05).Compared with blood stasis syndrome,TC and TG levels were significantly higher in patients with sputum turbid syndrome(P<0.05).Conclusions:1.It may have the same characteristics as body inflammation and oxidative stress response.2.In the Ⅲ,Ⅳ stage DN in the course of the disease,liver and kidney Yin deficiency syndrome of spleen and kidney deficiency syndrome.3.The body of phlegm turbidity may be related to the disorder of lipid metabolism.The method of eliminating phlegm and purging turbid may be helpful in regulating blood lipids and improving the prognosis of kidney.