Study On The Synthetic Technology Of Fluopyram

In crops,fungi cause more plant diseases than any ther group of microorganisms.In recent years,the development of antifungal agents has been developing rapidly,especially the succinate dehydrogenase inhibitors（SDHIs）,because of its unique mechanism of action,it has become a hot topic in major companies.As a typical representative compound of the new fungicide,the study on fluopyram is very important.Fluopyram,a typical pyridinyl moiety-contained phenylamide fungicide,which was comercialized by Bayer company,with low toxicity,high efficiency,low residue and environment-friendly.It can work on kinds of plant disease.Fluopyram is a potential fungicides,one has broad application prospects.The synthesis process of fluopyram was improved by consulting relevant paper.The key intermediate 2-（3-choloro-（trifluoromethyl）pyridine-2-yl）ethan-1-amine hydrochloride was obtained by condensation of the starting material 2,3-dichloro-5-（trifluoromethyl）pyridine with ethyl-2-cyanoacetate,and then the targeted compound fluopyram was got after decarboxylation,reduction,deprotection reactions,as well as amidation with2-（trifluoromethyl）benzoyl chloride.The reaction factors and parameters were optimized to obtain high yield and good quality.Under the optimized conditions has the advantages of simple operation,convenient work up,the total yield of fluopyram reached 48.1%（counted based on 2,3-dichloro-5-（trifluoromethyl）pyridine）.The structure of fluopyram was confirmed by IR、ESI-MS,¹H-NMR and ¹³C-NMR.The present method has the advantages of mild reaction condition and good yield.