Tte Study Of TCM Syndromes In The Treatment Of Children With Primary Nephrotic Syndrome At Different Dosage Of Glucocorticoid

ObjectiveBased on 172 cases of primary nephrotic syndrome children from in-patient department and section for outpatients.By observing the main TCM symptoms after taking different doses of glucocorticoid,the TCM syndromes were summarized,and then exploreing the law of TCM syndromes in children with PNS at different doses of hormone in order to guide the clinical.MethodsMake a unified observation list of TCM syndromes,accurately and truthfully record the symptoms,tongue images and pulse condition of the children in the observation table with the cooperation of the parents.The children were questioned by questionnaire at different stages.After the observation is over,uniformly judge the TCM syndromes of the children in accordance with the standard of syndrome differentiation.The incidence of different syndromes at different dose stages was analyzed.ResultsFirst,in the deficiency syndrome hand,comparison between the different dosage stages of hormone and the TCM syndromes,there were significant difference(P<0.05).There was qi deficiency and yang dificiency syndrome before gluococrtiocsteorid treatment,with yang deficiency(64.5%)mainly;In the [1.5,2]mg/kg·d phase,there was The proportion of qi deficiency syndrome and yang deficiency syndrome decreased significantly,Yin deficiency syndrome and qi and yin deficiency syndrome began to appear,with yin deficiency mainly;In the stage of [1,1.5)mg/kg·d,Yin deficiency(63%)was the main syndrome,followed by Qi and Yin deficiency syndrome(33.3%).At the stage of[0.5,1)mg/kg·d,the yin and yang deficiency syndrome began to appear in this stage,with yin deficiency syndrome(41.5 %)and Qi Yin deficiency syndrome(46.3 %).In the stage of [0,0.5)mg/kg·d,qi deficiency syndrome,yang deficiency syndrome,qi and yin deficiency syndrome and yin and yang deficiency syndrome can be seen,and there is no pure yin deficiency syndrome.In this stage,qi deficiency syndrome and qi yin deficiency syndrome are the main ones.Second,in the Standard demonstration hand,comparison between the different dosage stages of hormone and the TCM syndromes,there were significant difference(P<0.05).Before hormone therapy,there were water dampness syndrome,dampness and heat syndrome,dampness and turbid syndrome,blood stasis syndrome.In the [1.5,2]mg/kg·d stage,the water wet syndrome and dampness turbidity were significantly reduced,while the damp heat syndrome increased.This stage was mainly damp heat syndrome(61.8%).In the[1,1.5)mg/kg·d phase of daily dose of hormone,the dampness and turbid syndrome decreased further,and the dampness and heat syndrome was still the main factor.In the [0.5,1)mg/kg·d stage of daily hormone dose,the proportion of dampness and heat was still the highest(36.6%),and the dampness and turbid syndrome increased.In the phase of hormone dose [0,0.5)mg/kg·d,the proportion of dampness turbidity was the highest(66.7%)and the dampness and heat syndrome decreased.During the whole course of hormone therapy,the blood stasis syndrome was obvious.ConclusionPNS children showed dynamic changes in TCM syndrome type to use hormone therapy process.The deficiency of the hand,In the process of using hormone,the law of TCM syndrome change is Qi deficiency syndrome,Yang deficiency syndrome,Qi-Yin deficiency syndrome,Yin-Yang deficiency syndrome increase with the decrease of hormone dose,and yin deficiency syndrome decreases with the decrease of hormone dosage.The distribution characteristics of syndromes were as follows:before medication mainly with Qi-deficiency syndrome or Yang-deficiency syndrome..In[1.5,2]mg/kg·d stage,Yin deficiency syndrome is the main factor,in [1,1.5)mg/kg·d stage,yin deficiency syndrome is the main factor,and Qi deficiency is also the main factor.In [0.5,1)mg/kg·d stage,Yin deficiency syndrome is the main factor and qi deficiency is the main factor when the dose is near the upper limit of dose,and Qi deficiency syndrome is also yin deficiency when the dose is near the lower limit.In the stage of[0,0.5)mg/kg·d,Qi deficiency is the main syndrome and yin deficiency and yang deficiency are the main syndromes.Standard empirical aspects,thechange rule of TCM syndrome is: the damp heat syndrome decreases with the decrease of hormone dose,and the damp syndrome increases with the decrease of hormone dosage,and the blood stasis syndrome does not change with the decrease of hormone dosage.The syndrome of water dampness,dampness and heat,blood stasis,dampness and turbidity were all obvious before the use of hormone.In the course of hormone use,damp-heat syndrome decreases with the decrease of hormone dose,dampness turbid syndrome increases with the decrease of hormone dose,and blood stasis syndrome does not change with the decrease of hormone dose.In [1.5,2]mg/kg·d stage,damp-heat syndrome mainly,while in [1,1.5)mg/kg·d stage,damp-heat syndrome mainly.In[0.5,1)mg/kg·d stage,dampness and heat syndrome,blood stasis syndrome mainly,and in[0,0.5)mg/kg·d stage,dampness and turbid syndrome mainly.Blood stasis syndrome throughout the course of the disease from beginning to end.