| [Objective]: Lung cancer is a very common type of malignant tumor.At present,TNM staging system is generally used to evaluate the prognosis of patients in clinical practice.A large number of clinical studies indicate that there is the same TNM staging primary The survival time of non-small cell lung cancer patients after surgery is often inconsistent.In this study,immunoscores were performed by observing the number of CD3+ and CD8+ positive cells in the tumor center area and the tumor infiltrating border area in the pathological section of NSCLC patients.The total immune score was obtained to evaluate the prognosis of the patients and compared with the TNM stage.The prognosis of lung cancer is more valuable so that individualized treatment options can be selected and tumor control effects evaluated.[Methods]: A total of 45 NSCLC patients who were able to collect complete medical records from January 2011 to December 2013 in the Department of Oncology,Municipal Hospital of Qingdao were collected,including 30 adenocarcinomas and 15 squamous cell carcinomas.All patients were staged according to the latest International Association for the Study of Lung Cancer(IASLC)version 8 lung cancer TNM staging criteria,and overall Survival(OS)and disease-free survival(Disease)were followed up for follow-up patients.Free Survival,DFS).All patients had postoperative pathological wax masses and excluded pathological specimens.The paraffin blocks were subjected to immunohistochemical staining for CD3 and CD8 after the unfolding process.Two pathologists underwent light microscope observations of the tumor center(CT)and CD3+ and CD8+ of the invasive margin(IM).Positive cell density,followed by immunoscore,1 point for high densitometry and 0 for low density,after which the tumor patient’s CD3+ and CD8+ cells were summed in the CT and IM regions to obtain a total score for immunization(0-4 points),so the total can be divided into 5 staging.Finally,the predictive value of OS and DFS was compared between the two types of staging,and the difference between the score of 0 in the group and the score of 4 in the immunization group was statistically significant(P<0.05).All data analysis in clinical studies was done using the SPSS24.0 tool.[Result]: 1.Differences in OS and DFS between patients showing the same TNM staging by standard deviation and coefficient of variation(CV)comparisons.Analysis of variance showed that differences in TNM staging of patients with NSCLC did not result in a significant difference in OS(P=0.046)DFS(P=0.07).2.Comparison of standard deviation and coefficient of variation(CV)showed no significant difference in OS and DFS among patients with the same immune score.Analysis of variance showed that there were differences between OS and DFS in patients with different immune scores(P<0.05).We found that there was a significant difference in overall survival and disease-free survival from 4 points in patients with a score of 0 on the immune score,which was statistically significant.The survival time and disease-free survival time of the 4-point patient were relatively long.After the post-hoc comparison by LSD method,the OS of the two groups was different(P<0.001),and the DFS of the two groups also had significant differences(P<0.001).).[Conclusion]: There is a significant difference in OS and DFS after surgery in patients with the same TNM staging.Different TNM staging does not result in significant differences in OS and DFS.There was no significant difference in OS and DFS between patients with the same immune scores,and there were differences between OS and DFS in patients with different immune scores,suggesting that the NSCLC immune scoring system may be a better method for assessing prognosis. |
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