| Objective :To review the situation of D-dimer and platelet in patients with gastric cancer and precancerous diseases,and to increase the understanding of gastric cancer and precancerous diseases;Methodology:Collection for the period from January 2015 to December 2017,among of the patients diagnosed with chronic atrophic gastritis,gastric polyp,gastric ulcer,gastric stump disease,first-visit gastric cancer(first-diagnosed and untreated)in the Second affiliated hospital of dalian medical university,there were 116 cases of chronic atrophic gastritis,116 cases of gastric ulcer,109 cases of gastric polyp,124 cases of gastric remnant disease and 112 cases of gastric cancer as experimental group.By systematic sampling,110 cases of chronic non-atrophic gastritis in hospital of the same period were diagnosed as chronic non-atrophic gastritis.All patients were required to have no blood disease,no history of smoking,and no history of operation.And anti-platelet and anticoagulant drugs were not taken one month before admission,and no blood transfusion and plasma products were taken.SPSS22.0 statistical software was used for statistical analysis to compare the changes of D-dimer and platelet in eachexperimental group and control group,and then according to the general situation of each pre-cancerous disease group,clinical manifestations,gastroscopic manifestations,pathological conditions were grouped to compare D-dimer,platelet.Metrological data with mean standard deviation,P < 0.05 was statistically significant.Results :1.The values of D-dimer and platelet in gastric cancer group were higher than those in the control group,the difference was statistically significant(P < 0.05);d-dimer and platelet in patients with gastric remnant disease and chronic atrophic gastritis were higher than those in control group,but the difference of D-dimer was statistically significant(P < 0.05),but there was no statistical difference in platelet significance(P > 0.05);d-dimer and platelet of the patients in the gastric ulcer group were higher than that of the control group,and the difference was statistically significant(P <0.05).2.D-dimer and platelets in gastric cancer group were higher than those in the four precancerous diseases group,Except D-dimer in gastric stump group and gastric cancer group,there was no significant difference(P> 0.05),and other differences were statistically significant(P < 0.05).In the comparison of D-dimer,the mean values in order of size were gastric polyp,chronic atrophic gastritis,gastric ulcer,gastric stump and gastric cancer.In the comparison of platelets,the mean values were: gastric polyp,chronic atrophic gastritis,remnant stomach,gastric ulcer and gastric cancer.3.Analysis of Different Clinical Factors in patients with Chronic Atrophic Gastritis,the general conditions(sex,genetic history,age),the appearances under gastroscope(Hp infection,reflux,etc.),pathology(intestinalization and so on)had little effect on D-dimer.The D-dimer values of the patients with upper gastrointestinal bleeding were higher than those of abdominal pain,acid reflux and abdominal distension(P < 0.05),and the difference was statistically significant(P < 0.05).4.The general conditions(sex,age,family history),gastroscope manifestation(Hp infection,gastric ulcer active type,reflux),pathology(intestinal metathesis,heterosis,etc.)had little effect on D-dimer and platelets in patients with gastric ulcer.The platelets of the patients with bleeding and perforation were higher than those of the other patients,so there was no significant difference between the two groups(P>0.05).However,in the comparison of D-dimer in patients with gastric ulcer,the values of D-dimer in patients with perforating and bleeding symptoms were higher than those in other symptoms(P<0.05).The difference was statistically significant(P<0.05).5.The general conditions(sex,age,family history),primary pathologist,gastroscope condition(with or without reflux and Hp infection)had little effect on D-dimer and platelets in patients with gastric stump disease.The D-dimer in patients with primary malignant disease was higher than that in patients with benign disease,but the difference was not statistically significant(P>0.05).The D-dimer in the patients with gastric remnant diseases who were admitted to hospital due to gastrointestinal bleeding was higher than that in the other symptom groups,but the difference was not statistically significant(P>0.05).The D-D of gastric stump cancer was higher than that of gastric stump ulcer and gastric stump ulcer(P < 0.05)in patients with gastric stump ulcer than those with gastric stump ulcer.The difference was statistically significant(P< 0.05).Conclusion:D-dimer and platelet increased in patients with gastric cancer.D-dimer increased in patients with gastric remnant disease and chronic atrophic gastritis.D-dimer and platelet elevation were found in patients with gastric ulcer.Patients with bleeding and perforation can affect the changes of D-dimer and platelets.1.D-dimer and platelet already increased in precancerous disease;2.It is a good use in find gastric cancer which increased in D-dimer and platelt;3.The intimate element with gastric cancer such as family history、the infection of Hp 、 the atrophy of gastric and precancerous lesions is irrelevant to the increase of d-dimer and platelet... |
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