Fluorescein Sodium-guided Resection Of Glioma Of Clinical Application Study

BackgroundGlioma is a very common neurosurgical malignant neoplasm in neurosurgery.According to relevant research data,it accounts for about 40%-60%of intracranial tumors,which not only have a high incidence,but also show patients with The clinical symptoms are quite complicated.The recurrence rate after treatment is extremely high.The patient’s prognosis is poor and the death rate is high.It has become a serious killer of human health.The treatment of glioma varied,craniotomy resection of the lesion is the main treatment of glioma,with the development of microsurgery,microsurgery has gradually replaced the traditional open surgery,becoming the mainstream of the treatment of glioma Surgical approach.Glioma has a high degree of malignancy and poor prognosis,which seriously affects the survival time and quality of patients.As many resections of the tumor as possible during the initial operation can significantly improve the quality of life of patients.In recent years,many new technologies have been applied in the surgical treatment of gliomas,such as intraoperative real-time neural navigation stereotactic technique,intraoperative real-time magnetic resonance imaging technology,intraoperative real-time B-guided technology.Fluorescence guided microsurgery resection of tumor through fluorescent substances to stain the tumor tissue,the surgeon can more accurately determine the boundaries of the tumor and normal brain tissue,to ensure maximum brain function under the premise of tumor removal.At present,the new technology of sodium fluorescein-guided microsurgery has been applied in many medical centers and institutions both at home and abroad.Relevant applications have confirmed that the application of sodium fluorescein-guided microsurgery to glioma surgery can help us to significantly improve the tumor Full rate,improve patient quality of life and prognosis.ObjectiveTo investigate the application and efficacy of fluorescein sodium in the surgical treatment of glioma and to provide a clinical reference for the treatment of glioma.MethodsThe clinical data of eligible patients who were admitted from January 2016 to June 2017 were collected and 30 patients were eligible after screening.The clinical data of 30 patients with gliomas were retrospectively analyzed.Of the 15 patients,Sulfate development guided the surgical treatment,intraoperative microscope fluorescence mode,according to the scope of the fluorescence imaging to determine the border of the tumor,15 cases of the control group underwent traditional microsurgery surgery,the tumor part of the body take a pathological,Two groups of patients were routinely performed MRI enhanced scan within 3 days after operation.The degree of resection was estimated according to the scope of enhancement and compared.The operation time,hospitalization time,and progression-free survival rate of 6 months were compared between the two groups.UsingX2 tests for analysis.Results(1)Sodium fluorescein guide microsurgical group after filtering the total 15 cases,conventional filtering even after microsurgery total group into 15 cases.Sodium fluorescein sodium-guided microsurgical group of patients without fluorescein sodium fluorescein sodium adverse reactions.(2)Craniocerebral MRI was performed within 72 hours after operation.Fourteen patients(93.3%)underwent microsurgical treatment with fluorescein sodium and 9 patients(60.0%)underwent traditional microsurgery.There was significant difference between the two groups(P<0.05).(3)The 6-month progression-free survival rate was 73.3%in the fluorescein-sodium-guided microsurgery group and 66.7%in the 6-month conventional microsurgery group.There was a significant difference in progression-free survival between the two groups at 6 months(P<0.05).Conclusion(1)Intraoperative application of fluorescein sodium guide surgery to remove glioma compared with conventional microsurgery can significantly improve the rate of tumor resection,which is particularly evident in the surgical treatment of high-grade glioma.(2)Compared with the traditional microsurgical Department of Neurosurgery,the fluorescein sodium guided surgery did not show much difference before and after the operation.(3)The operation of fluorescein sodium guided surgery for glioma related excision can increase the life free life of the personnel well,and reduce the time of hospitalization,which has important clinical significance and social value.