The Resting State FMRI Study Of Limbic System In Migraineurs Without Aura

PartⅠ : Altered brain activity and connectivity of the cingulate cortex in migraine without auraObjective: To evaluate abnormal local temporal neural activities and functional connectivities(FCs)of subregions within the cingulate cortex of patients with migraine without aura(MWOA)in interictal periods.Methods: Resting-state functional magnetic resonance imaging(rs-fMRI)was used to examine 20 patients with MWOA and 20 age-and gender-matched healthy controls.Regional homogeneity(ReHo)was primarily utilized to analyze the between-group differences in local spontaneous brain activities in the cingulate cortex.The FC between abnormal ReHo regions and other brain regions was then calculated,and the associations of the ReHo and FC values with the clinical features of patients with MWOA were examined.Results: The patients with MWOA exhibited a significant reduction in the ReHo values in the right anterior cingulate cortex(ACC)compared with those of the healthy controls.FC also decreased between the right ACC and the left dorsal lateral prefrontal cortex,medial prefrontal cortex,right temporal pole,posterior cingulate cortex,and precuneus in patients with MWOA.The ReHo values of the right ACC were negatively correlated with disease durations,and the FC values between the right ACC and right temporal pole were negatively correlated with Hamilton Anxiety Scale scores.Conclusion: The abnormal activity and connections of the right ACC may play an important role in migraine expression.This study highlighted the neurolimbic influence on the mechanism of migraine and provided further insights into clinical and research approaches for migraine.Part Ⅱ:Functional connectivity analysis of anterior insula in migraine without auraObjective: To investigate the altered functional connectivity(FC)of anterior insular in patients with migraine without aura(MWOA)and its clinical significance.Methods: 20 patients with MWOA and 20 healthy controls were explored in our study.The differences of resting-state FC based on the bilateral anterior insulars between two groups were analyzed,and the correlations between abnormal FCs and clinical symptoms were calculated.Results: Compared with healthy controls,migraineurs exhibited decreased FCs between anterior insular and right posterior centeral gyrus,bilateral middle cingulate gyri,right middle frontal gyrus,bilateral supramarginal gyri,and right middle temporal gyrus.No increased FC and no correlation between abnormal FCs and clinical symptoms was found.Conclusion: Brain regions showing altered FCs with bilateral anterior insulars in migraineurs are those involved in sensory-discriminative processing of pain,affective-emotional processing,cognitive processing and visual processing.And these abnormal FCs may provide new insight into the investigation of pathophysiology for migraine.