Relationships Between Bone Mineral Density,Bone Turnover Markers And Endothelial Function In Postmenopausal Women With Type 2 Diabetes Mellitus

Objective:To analyze the relationships between the bone mineral density(BMD),bone turnover markers(BTMs)and vascular endothelial function in postmenopausal women with type 2 diabetes mellitus(T2DM).Methods:A total of 58 postmenopausal women with T2DM were enrolled in this study from September 2017 to May 2018 in Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University.All subjects were tested for biochemical indexes,bone mineral density(BMD)at lumbar vertebrae(L1,L2,L3,L4,total)and hip(femoral neck,large rotor,femur trochanter,Ward’s triangle,total)by the Dual Energy X-ray Absorptiometry(DXA)and vascular endothelial function by Endo-PAT2000 to get reactive hyperemia index(RHI).According to the diagnostic criteria of osteoporosis,fifty-eight postmenopausal women with T2DM were divided into osteoporosis group(OP,n=24)and non-osteoporosis group(NOP,n=34).Results:The level of RHI in OP was slightly lower than this in NOP(1.42±0.56 vs 1.43±0.36,P>0.05).The bone formation marker:type 1 procollagen N-peptide(P1NP)、the bone absorption marker:type 1 collagen protein C-terminal crosslinking peptide(CTX)and BMD at lumbar vertebrae(total)and hip(neck,total)showed a tendency of weak positive correlation with RHI(P>0.05),glycosylated hemoglobin(HbA1C)presented a tendency of negative correlation with RHI(P>0.05),and there were no statistical difference(P>0.05).Conclusion:There is no correlation between BMD and BTMs and vascular endothelial function in postmenopausal women with T2DM.