Basic Research On The Standard Decoction Pieces Of Phellodendri Chinensis Cortex And Phellodendri Chinensis Cortex

Phellodendri Chinensis Cortex,a traditional chinese medicine that commonly used in clinical practice,was first recorded in the "Shennong’s Herbal Classic" as a top grade,as the famous as "Mark herbs" with Eucommiae Cortex and Magnoliae Officinalis Cortex.Phellodendri Chinensis Cortex is provided with the effect of clearing pathogenic heat and eliminating dampness,purging fire and detoxification,clearing hectic heat.It was used for the treatment of bone steaming and hectic fever,damp heat and sore,eczematid and pruritus,jaundice,red urine,night sweating,spermatorrhea.Modern society mainly used for the treatment of infectious diseases such as diarrhea,arthritis,pneumonia,chronic hepatitis,allergic drug eruptions.Objective At present,the quality evaluation standards of Phellodendri Chinensis Cortex and its processed products are not enough,lack of the exclusive evaluation of the characteristic attributes of the scientific connotation decoction pieces before and after the processed,especially.In order to further improve the quality evaluation system of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces,to evaluate the specificity of raw and processed decoction pieces,and to ensure the quality of decoction pieces to improve the clinical curative effect,this paper choose Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces as the research object to start Standard decoction pieces preparation technology study.Method According to the standard collection and processing methods to collected raw materials and entrust companies with GMP certification according to the standardized technology to product Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces and candidates standard decoction pieces,through the systematic study of the quality attributes of the candidate standard decoction pieces,we established the technical specifications for the collected and processed of Phellodendri Chinensis Cortex raw materials,the processing of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces,the attributes identification of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex candidates standard decoction pieces.At the same time,we carry out the applicability test of the quality criteria of candidate standard decoction pieces by using the standardized production enterprise’s decoction pieces products.In addition,the objective of the color quantitative analysis of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces with the Color colorimeter,we also studied the correlation between the color and the main chemical components of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces,to further clarified the variation of the chemical composition before and after the charred.Results Through the above research work,the technical specification for the collected and processed of Phellodendri Chinensis Cortex raw materials,the processing of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces,the attributes identification,homogenization,packaging and storage of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex candidates standard decoction pieces was setted,to improved the quality evaluation criteria of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces,through applicability test on the quality criteria of the candidate standard decoction pieces initially established,finally form the quality criteria(draft)of the Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex candidate standard decoction pieces.Conclusions This paper carried out the basic research of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex standard decoction pieces,formed a more complete research system of Chinese medicine standard decoction pieces at the first time.Through the attributes identification of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex candidates standard decoction pieces,we established the quality evaluation criteria of Phellodendri Chinensis Cortex decoction pieces with the nine chemical components as indexes and the specific quality of charred Phellodendri Chinensis Cortex decoction pieces with the two chemical components as indexes.The single component simulation experiment was carried out to analyze the conversion of the main component berberine of Phellodendri Chinensis Cortex at different degrees of charred,and reveal the variation rules of the main chemical components of the Phellodendri Chinensis Cortex before and after charred.In addition,the color analysis technology of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces was first used in this thesis to provide a scientific basis for objective quantification of process parameters of Phellodendri Chinensis Cortex and charred Phellodendri Chinensis Cortex decoction pieces.