Application Study On Ultrasound Elastography In HIFU Temperature Monitoring

High intensity focused ultrasound treatment technology is a non-interventional treatment on the rise in 90s,the focus of temperature is 65 degrees centigrade,currently mainly used in the treatment of prostate cancer,pancreatic cancer,liver cancer,bladder cancer and uterine leiomyoma.Due to the lack of stability and reliability of non-invasive temperature measurement technology,the actual temperature of the focus area is not clear in the actual treatment of clinical HIFU,making the quantitative treatment of HIFU difficult.If do not know the actual temperature of the target area,continued heating may be painful to patients,and low temperature may not meet the requirements of treatment.Therefore,research and development of practical non-invasive temperature measurement technology imminent.Intuitive and effective quantitative monitoring indicators of thermal safety will form a more perfect HIFU clinical treatment standards.This method will reduce treatment risk and improve treatment effect.Currently,based on various ultrasonic imaging guide HIFU treatment system,also lacks the key functions of monitoring and evaluation of the target thermal safety and tissue coagulation necrosis degree to ensure the safety and effectiveness of treatment on the market.Due to the formation of HIFU tissue damage mainly in the nuclear fragmentation or pyknosis,protein denaturation,cell damage and surrounding tissue edema,pathological changes of these tissues leads to tissue elasticity changes,manifested as regional organizations of hard HIFU thermal ablation is significantly greater than the surrounding normal tissues.Therefore,this paper based on the two-dimensional ultrasonic radiation force imaging quantitative color elastic core technology based on the integration and improvement of the other existing ultrasonic non-invasive measurement method to establish "temperature viscoelastic" tumor pathological tissue of the calibration curve and the corresponding fast algorithm,obtained from the thermal distribution and thermal diffusion the target area and the surrounding healthy tissue during the process of ultrasonic energy in the treatment of thermal safety information,ultrasound acoustic radiation force based on the two-dimensional quantitative ultrasound elasticity imaging algorithm will be conducive to the realization of real-time assessment of thermal safety monitoring and postoperative curative effect of HIFU therapy.According to the pathological tissue to establish its viscoelastic curve with the temperature change,and study the relationship between biological tissue with viscoelastic coagulation necrosis degree.This is a new way of thinking and research direction for the research of HIFU tumor therapy system with ultrasound guidance and monitoring.At the same time,improved estimation algorithm for 2D real time shear wave velocity and to improve the measuring stability and reliability also is a very valuable research direction,and research and exploration is necessary for the system.