Mechanisms Of Neuroprotection By Curcumin In Acute Epileptic Rat

Objective:To discuss the antiepileptic and neuroprotective effects of curcumin in epilepsy modeled by PTZ intraperitoneal injection.Medthods:The 48 SD male rats were randomly divided into four groups:curcumin group,control group,model group and curcumin intervention group,12 rats in each group.To establishe acute animal model of epilepsy by PTZ intraperitoneal injection,we observed the behavior performance of each group.Observing pathological changes of each group by HE and Nissl staining,apoptosis by Tunnel staining.The expression of LC3-Ⅱ and Beclinl in hippocampus or cortex was investigated by immunohistochemical staining.Results:Compared with epilepsy model group,the duration of the experimental group was obviously prolonged;In pathological changes,the experimental group has a significant improvement;But,the Autophagy-Related Proteins,LC3-Ⅱ and Beclinl,were no significant difference in each group(p>0.05).Conclusions:Curcumin significantly inhibited the occurrence of epilepsy and alleviated neurons damage,playing a role in antiepileptic effect.Its mechanism may be related to the antioxidant,anti-inflammatory properties and neuroprotective effects by curcumin,independenting of Autophagy-Related mechanism.