Synthesis And Antioxidant Activity In Vitro Of 2-methylsulfona-quinoline Derivatives

Quinoline derivatives,which play an important role in the field of food processing,agricuItural chemicals industry,drug,filtration etc.,are important organic heterocycle.its derivatives exhibits a variety of pharmacological activities including antiinflammation,antioxoidant,antimalaria.In this work,we design and synthesis some new Quinoline derivatives,based on the intellectual of structure-activity relationship.Their antioxoidant activities were detected with DPPH.O2-·,HO·method.A mild approach for direct C2 sulfonylation of heteroaromatic N-oxideswith sulfonyl hydrazides affording 2-sulfonyl quinolines/pyridines has been developed.A variety of heteroaromatic N-oxides and sulfonyl hydrazides participate effectively in this transformation which uses hypoiodites(generated in situ from Nal and TBHP)as a means of substrate activators.In this reaction,the N-oxide plays a dual role,acting as a traceless directing group as well as a source of oxygen atom.This paper reports the results obtained for antioxidant activity in vitro of 2-Methylsulfona-quinoline Derivatives,The evaluation of antioxidant activity was carried out by reducing power,hydroxyl,superoxide anion and DPPH radical scavenging assays in comparison to GSSG and GSH.The antioxidant abilities of curcumin analogues were detected by DPPH method.These products had shown certain antioxidant activity.The product 3j showed better antioxidant activity.