Analysis Of Clinical Features Of Renal Carcinoma Associated With Xp11.2 Translocation/TFE3 Gene Fusion

Objective:Xp11.2 translocation/TFE3 gene-associated renal cancer is a rare clinical subtype of kidney cancer of the 2004 WHO renal tumor classificationin,referred to as Xp11.2translocated renal cancer or TFE3 RCC.The clinical incidence of Xp11.2 translocation renal cell carcinoma is not only low,but also a new classification of renal tumors.People lack awareness and it is often misdiagnosed.This article aims to investigate the characteristics of diagnosis and treatment of Xp11.2 translocation renal cell carcinoma,deepen the understanding of the disease,and improve the level of clinical diagnosis and treatment.Methods:Reviewe the clinical data of one pathological diagnosis of Xp11.2translocation/TFE3 gene-associated renal cell carcinoma diagnosed in August 2017 in our hospital.Consult the relevant literature reports and comparative analysis.Summarize the clinical features of the disease.Results:Xp11.2 translocation/TFE3 gene fusion-associated kidney cancer is slightly more young females,gross hematuria is more common than renal clear cell carcinoma;CT plain scan is prone to calcification,and enhanced arterial phase enhancement is significantly smaller than renal clear cell carcinoma,showing "less Progressive-slow-out enhancement(moderately enhanced arterial phase,further enhancement of venous phase,slow decay of delayed phase);diagnosis relies mainly on immunohistochemical TFE3(+),gene detection as a diagnosis of Xp11.2 translocation renal cell carcinoma "Golden criteria";treatment preferred radical radical nephrectomy;poor prognosis.Conclusion:Xp11.2 translocation/TFE3 gene fusion-associated renal cancer should be considered if young patients with renal septum,preoperative CT scans showed significant calcification and enhanced with "less forward-slow out" type enhancement;Consider Xp11.2 translocation/TFE3 gene fusion-associated renal cancer higher invasion of the collection system and it is recommended that radical resection of renal cancer be performed as soon as possible.