| Objective:To observe the levels of plasma NLRP3 and its downstream inflammatory cytokine interleukin-18(IL-18)in patients with different degrees of coronary angiopathy,and to investigate the correlation between the level of NLRP3,IL-18 and the coronary stenosis and the stability of coronary sclerosing plaque and its clinico worth.Methods:From January 2016 to November 2017,113 patients with CHD who were admitted to the Department of Cardiology at the Second Medical College of Shanxi Medical University were selected as the case group.There were 63 male patients and 50 female patients.The average age was 61 years±10.At the age of one year,all patients were diagnosed with coronary artery disease by coronary angiography.The diagnostic criteria for coronary heart disease were coronary angiography.The results showed that there was at least one major coronary artery stenosis ≥ 50%.At the same time,38 patients who were hospitalized in the Department of Cardiology at the same time were selected as the control group.All patients had undergone coronary angiography except coronary heart disease,including 17 male patients and 21 female patients.The average age was 61years±7 years.The NLRP3 and IL-18 ELISA kits were used to measure the plasma levels of NLRP3 and IL-18 in all subjects.The Gensini score was used to evaluate the patients’ Gensini scores.Pearson correlation analysis was used to analyze the correlation between the level of plasma NLRP3、 IL-18 and the Gensini score in patients with coronary heart disease.Results:(1)There was no representational difference in age,sex,blood pressure(systolic/diastolic blood pressure),body mass index,total cholesterol,triglycerides,HDL-C,history of hypertension,history of diabetes,and smoking history among these groups of patients(P>0.05).These distinction is worthless(P>0.05),but the level of serum LDL-C in the AMI group was meaningfully higher than that in the control group(P<0.05).(2)In terms of the single-vessel and double-vessel disease groups,The level of plasma NLRP3 and IL-18 in patients with multi-vessel disease were dramatically higher than them(P<0.05).(3)Account of the mild,moderate and severe lesions,the levels of plasma NLRP3 and IL-18 in the extremely severe lesions were increased significantly(P<0.05),whereas for the mild lesions,the levels of the plasma IL-18 in the severe lesions rise remarkably(P<0.05).In terms of the mild and moderate lesions,the Plasma NLRP3 levels in severe lesions grow obviously(P<0.05).(4)Compared to the control group,the levels of Plasma NLRP3 and IL-18 in patients with AMI,UAP,and SAP advancing overtly(P<0.05).Compared with the SAP group,the degree of plasma NLRP3,IL-18 and Gensini scores were distinctly elevate in patients of the AMI and UAP group.The level of 18 and Gensini scores were significantly higher(P<0.05).The Gensini scores and the levels of plasma NLRP3 and IL-18 were valuable in the AMI group than the UAP group(P<0.05).(5)There was a medium positive correlation between the degree of plasma NLRP3 and Gensini scores(P<0.01);a weak active correlation between plasma IL-18 severity and Gensini scores(P<0.01);the plasma NLRP3 levels and IL-18 levels has a moderate absolute correlation(P<0.01).Conclusion:(1)The increase of plasma NLRP3 and IL-18 degree in patients with coronary heart disease is closely related to the coronary stenosis and the stability of coronary sclerosing plaque.As far as Im concerned,the unique marker may be severed as a predictor of acute cardiac events in patients with coronary heart disease.(2)NLRP3 inflammasome may exert its evident effects through its downstream inflammatory factor IL-18. |
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