The Relationship Between Hepatitis B Associated Chronic Liver Disease And Helicobacter Pylori Infection

Objective:Helicobacter pylori(Hp)infection is prevalent in the human population.At present,the Helicobacter pylori infection rate in China is still about 50%.An increasing number of studies have demonstrated that H.pylori may cause liver diseases,and the underlying relationship between H.pylori infection and Hepatitis B virus(HBV)has attracted much attention.The purpose of this study is to investigate the relationship between Helicobacter pylori infection and hepatitis B-related chronic liver disease,and to increase the importance and treatment of Helicobacter pylori infection in hepatitis B-related chronic liver disease.Methods:A total of 117 patients with liver diseases admitted to our hospital from January 2012 to January 2018 and from the Third People’s Hospital of Taiyuan from June 2017 to December 2017 were collected.There were 40 patients with chronic hepatitis B,56 patients with hepatitis B cirrhosis,and 21 patients with liver cancer after hepatitis B.Collected the case data,and recorded the general conditions of the study subjects:general information including gender,age,and diagnosis,at the same time,laboratory tests such as blood routine,liver function,coagulation series,and hepatitis B virus DNA(HBV-DNA)were recorded.For chronic hepatitis B,the five outcomes of hepatitis B were collected.And patients with hepatitis B cirrhosis were graded according to Child-pugh criteria.H.pylori detection was used serum Ig G antibodies,rapid urease test and13C/14 C breath test.Analyze the relationship between H.pylori and the relevant laboratory parameters of hepatitis B-related chronic liver disease.Results:1.The difference in Hp infection rate between the three groups was not statistically significant(P=0.648).2.There was no statistically significant difference in the Hp-positive rate of chronic hepatitis B between e antigen-positive and e antigen-negative hepatitis B(P=0.719).3.In the hepatitis B cirrhosis group,there was no significant difference in the positive rate of Hp among different Child-pugh grades(P=0.720).4.There was a significant difference in Alanine aminotransferase(ALT),Aspartate transaminase(AST)and Valley aminotransferase(GGT)between the three groups(P<0.05).5.Among all the subjects,the levels of AST,Total bilirubin(TBIL),Alkaline phosphatase(ALP),GGT and Prothrombin time(PT),in the Hp-positive group were higher than those in the Hp-negative group,and the difference was statistically significant(P<0.05).The levels of the Albumin(ALB)and Prothrombin time activity(PT%)levels were significantly lower than those of Hp-negative group(P=0.000).6.In Chronic hepatitis B(CHB),the levels of AST,ALP,GGT and PT in Hp-positive patients were higher than those in Hp-negative patients(P<0.05).The levels of ALB and PT% of Hp-positive patients were lower than those of Hp-negative patients(P<0.05).In Hepatitis B cirrhosis,the levels of ALP and PT in Hp-positive group were higher than those in Hp-negative group(P<0.05).The levels of PLT,ALB and PT% in Hp-positive group were lower than those of Hp-negative group(P<0.05).In liver cancer,the levels of ALP,GGT and PT in the Hp-positive group were higher than those in the Hp-negative group(P<0.05).The levels of Hemoglobin(Hb)and ALB were lower than those of Hp-negative group(P<0.05).7.There was a difference in Hp infection rates of different HBV replication levels(P<0.05).Conclusion:1.The infection rate of Hp in Hepatitis B associated chronic liver disease has no difference.2.There is no difference in the Hp infection rate of CHB with e antigen-positive and e antigen-negative hepatitis B.3.In the hepatitis B cirrhosis group,there is no difference in the rate of Hp infection among different Child-pugh grades.4.Hp may aggravate hepatic function impairment of Hepatitis B associated chronic liver disease.5.Hp may affect the replication of HBV-DNA levels in Hepatitis B associated chronic liver disease.