| Objective:A retrospective study was conducted to investigate whether early enteral nutrition combined with probiotics could improve lung infection in patients and compare the number of white blood cells in peripheral blood,the percentage of neutrophils,and procalcitonin(PCT)in the observation group.There was a statistically significant difference between the days of hospitalization in the neurological intensive care unit,the duration of mechanical ventilation,and the improvement of infections during the establishment of artificial airway duration compared with the improvement in the control group.To investigate the effect of early addition of probiotics on the improvement of pulmonary inflammatory response in NICU patients who were given enteral nutrition via nasogastric tube.Provide some suggestions for clinical medication.Methods:Eighty cases of patients with NICU were collected and collected in strict accordance with the inclusion criteria and rejection criteria.They were divided into two groups.40 patients in the observation group were treated with probiotics and enteral nutrition during treatment,while 40 patients in the control group were not given probiotics during treatment.Intervention treatment.The number of peripheral blood leukocytes,the percentage of neutrophils,and serum procalcitonin(PCT)inflammation were collected in the early morning on the first day,the seventh day,and the fourth day of the onset of enteral nutrition.Response indicators,collecting GCS scores on the day of admission,number of days hospitalized in the neurological intensive care unit,ventilator use time,establishment time and duration of artificialIV channels,30-day improvement of lung infections,to evaluate the probiotics for lung infection in patients The clinical efficacy of treatment.The data collected in this case review analysis were analyzed statistically using SPSS13.0.Chi-square tests,rank sum tests,and multivariate analysis of variance were used.P<0.05 prompted statistically significant data.Results:Among 80 patients,except one patient who had recurrent cerebral hemorrhage during the course of treatment,which led to exacerbation of the disease,the remaining79 patients had improved 30-day lung infection.The average patient treatment period in the Neurosurgery Critical Care Unit was 29 days.Among them,the number of patients with a GCS score of 9-11 points was 43;the number of patients with a GCS score below 8 was 37;the number of patients with a history of smoking was 32;the number of patients without a history of smoking was 48 Cases,there are 36 cases of patients with basic diseases,44 cases of patients without basic diseases,33 cases of patients with aspiration,47 cases of patients without aspiration,and 46 cases without artificial airway 34 cases of artificial airways were established and 19 cases of mechanical ventilation were performed.Among the 80 patients,40 patients were included in the probiotic intervention group and 40 patient groups were compared.There was no significant difference in the basic condition between the two groups(P>0.05).There was no significant difference in the number of days of NICU hospitalization,duration of mechanical ventilation,duration of artificial airway establishment between the probiotic group and the control group(P>0.05).The improvement of the number of white blood cells on the 1st,7th,and 14 th days of enteral nutrition in the probiotic group was compared with that of the control group.There was a statistically significant difference between groups.(P<0.05).Conclusion:Early enteral nutrition combined with probiotics can reduce the inflammatory reaction of severe pneumonia in patients with NICU,but it does not change the pathogenesis of severe pneumonia;however,the effect of mild pneumonia in patients with NICU is not obvious. |
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