Correlation Between Subclinical Hypothyroidism And Left Ventricular Function In Peritoneal Dialysis Patients

Objective:To analyze the prevalence of subclinical hypothyroidism(SCH)in peritoneal dialysis(PD)patients and to investigate its relevance to left ventricular function.Methods:Ninety five patients with end-stage renal disease(ESRD),who had been on peritoneal dialysis for more than three months from November 2013 to December 2017 in Department of Nephrology,were enrolled into this study.According to the thyroid function,they were divided into SCH group and euthyroidism group.Their clinical data and biochemical indicators were collected.The thyroid function was measured by electrochemiluminescence.Cardiac ultrasound measurement of cardiac lumen diameter parameters and function were assessed by echocardiography.The differences in the clinical data and the indexes of the heart between two groups were observed,and the relationship between thyroid function and clinical data or the indexes of the heart was analyzed.Results:Among these 95 patients,42 cases(44.21%)patients had SCH.Total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C)and C-reactive protein(CRP)were significantly higher in SCH group than those in euthyroidism group(P<0.05),while left ventricular ejection fraction(LVEF)was lower in SCH group than those in euthyroidismgroup.Pearson correlation analysis revealed that TSH level was positively correlated with TC,TG,LDL-C and CRP,but negatively with LVEF.Multiple linear regression analysis showed that SCH and increased CRP were independent risk factor for decreased LVEF.Conclusion:The prevalence of SCH was relatively higher in PD patients.In PD patients,SCH is closely correlated to left ventricular dysfunction.