Clinical Features And Antibiotic Resistance Analysis Of Chryseobacterium Indologenes And Elizabethkingia Meningoseptica

Objective:To analyze the clinical features and antimicrobial resistance of Chryseobacterium indologenes and Elizabethkingia meningoseptica.Methods:1.We selected the clinical data of 49 Chryseobacterium indologenes isolates and 26 Elizabethkingia meningoseptica isolates in our hospital from November 2013 to October 2017 for retrospective analysis.2.122 and 55 non-repeated isolates of Chryseobacterium indologenes and Elizabethkingia meningoseptica respectively from January 2008 to October 2017 were collected for analysis of antimicrobial resistance.Results:1.As for Chryseobacterium indologene,all of the 49 cases have been accompanied with severe underlying diseases and treated with broad-spectrum antibiotics.43 cases have indwelling devices.39 cases have been admitted to ICU.Only the resistance rate of Sulfamethoxazole/Trimethoprim is less than 50%.2.In the case of Elizabethkingia meningoseptica,25 cases have been accompanied with severe underlying diseases and 22 treated with broad-spectrum antibiotics.21 cases have indwelling devices.18 cases have been admitted to ICU.The antimicrobial susceptibility of Piperacillin/Tazobactam and Sulfamethoxazole/Trimethoprim is higer than other antibiotics.3.In the periods studied,Chryseobacterium indologenes has no changes in antimicrobial resistance rate.As for Elizabethkingia meningoseptica,the resistance rate of levofloxacin is rising obviously.Conclusion:1.Chryseobacterium indologenes and Elizabethkingia meningoseptica isolated from our hospital are multi-drug resistant.2.Most of the patients have severe basic diseases,recently use of broad-spectrum antibiotics,invasive procedures,hospitalization history in ICU and prolonged length of stay.3.The colonization of Chryseobacterium indologenes and Elizabethkingia meningoseptica isolated in our hospital is common.4.The pattern of antibiotic resistance may change with time and the use of antimicrobials.