Comparison Of Anesthetic Effects Of Different Doses Of Propofol Combined With Sufentanil In Non-intubation Endoscopic Surgery

Objective:To study the effect of intravenous anesthesia with different doses of propofol on CO₂ in patients undergoing non-intubation endoscopic surgery,and to findout the optimal maintenance concentration of propofol,which has the least effect on CO₂.Methods:We included sixty patients undergoing painless gastroenteroscopy,they were randomly divided into three groups according to the maintenance concentration of propofol:group A(5mg/kg﹒h^-1),group B(7.5mg/kg﹒h^-1),group C(10mg/kg﹒h^-1).We monitored mean arterial pressure（MAP）,heart rate（HR）,oxygen saturation（SPO₂）,Transdermal partial pressure of carbon dioxide（tcpCO₂）,transdermal partial pressure of oxygen（tcpO₂）before induction（T0）,after induction 5min（T1）,after induction 10min（T2）,after induction 15min（T3）.Results:In group A,there were 5 patients with limb motility.One case of limb movement and one case of SpO₂ decrease in group B.In group C,there were 6 cases of severe carbon dioxide rise and 2 case of hypotension.Compare with group A and B,tcpCO₂ at T2,T3 was increased significantly（P<0.05）in group C.TcpO₂ at T1,T2,T3was increased significantly（P<0.05）in group B.Conclusion:Propofol sustained infusion of 7.5mg/kg﹒h^-1 had the least effect on carbon dioxide and was more suitable for anesthesia of non-intubation endoscopy outpatients.