The Relationship Between Serum Bilirubin Levels And The Severity Of Coronary Atherosclerosis In Patients With Type 2 Diabetes.

Objective: To investigate the relationship between serum bilirubin levels and the severity of coronary atherosclerosis in patients with type 2 diabetes.Methods:318 subjects of type 2 diabetic patients admitted to the Fourth Department Of Cardiovascular of Shengjing Hospital from January 2016 to June2017 were reviewed.According to the result of the coronary angiography,these patients were divided into non-coronary heart disease group and coronary heart disease group,in accordance with the modified Gensini scoring system to calculate the score of these patients.According to the score,dividing these patients into mild group,moderate group and severe group.The general clinical data of these patients were recorded and collected,including gender,age,hemoglobin,HbA1C、FPG、TC、TG、LDL、HDL,Scr,UACR,TBIL,DBIL,IBIL,HsCRP.The software SPSS24 was used to analyse these data.Results: In the coronary heart disease group,HbA1 C,FPG,TC,LDL,UACR,and HsCRP was higher than non-coronary heart disease group.While the TBIL、IBIL、HDL were lower than non-coronary heart disease group,the difference between the two groups was statistically significant,P <0.05.Whether suffering T2 DM as the dependent variable,Logistic analysis showed that HsCRP and LDL were the independent risk factors of CHD.TBIL was an independent protective factors for the CHD.The TBIL and IBIL were negatively correlated with Gensini score(r =-0.31,P<0.01,r =-0.568,P <0.01)There was a negative correlation between TBIL and HbA1 C,FPG and LDL,and positive correlation with HDL IBIL was positively correlated with HbA1 C,LDL and HDL Analysis of risk factors.With the severity of coronary artery stenosis increased,the TBIL 、IBIL were significantly decreased,the difference was statistically significant,P <0.01,The difference of the level of DBIL was not statistically significant,P > 0.05.Conclusion: 1.The decrease of TBIL and IBIL is an independent risk factor for type 2 diabetes with CHD.2.TBIL and IBIL decreased gradually with the level of the severity of coronary atherosclerosis in patients with type 2 diabetes.