Application Of Brain Diameter Measurement And CAP Score In The Diagnosis Of Huntington Disease

Objective: To study the application of the magnetic resonance imaging brain line diameters of 13 Huntington’s Disease pedigrees and CAP score in the diagnosis of Huntington’s Disease,and to further evaluate its practicability in clinical practice.Methods: Thirteen genetically-tested patients with Huntington’s disease from 13 families were recruited as the experimental group.Drawed the complete pedigree map and recorded clinical data including clinical signs and symptoms in detail,the subject’s natural condition,MMSE score and Mo CA score.30 healthy people served as control group,and brain line diameters which were selected to reflect the morphology of the lateral ventricle,basal ganglia,and cerebral cortex were measured by and SPSS 20.0 statistical software.Compare the differences in the diameters between the two groups and analyze the relationship between MMSE and Mo CA scores and MRI brain lines in experimental and control groups.The CAP scores were calculated if the CAG repeat sequence >40.According to the CAP score,13 patients were divided into high CAP group and low CAP group,and magnetic resonance brain diameters were compared between the two groups.Results: The pedigree maps of 13 pedigrees were completely drawn and all were in an autosomal dominant inheritance pattern.Thirteen patients with Huntington’s disease showed varying degrees of involuntary movements,mental disorders,and cognitive dysfunction.The cranial MRI showed bilateral caudate nucleus atrophy and an enlarged anterolateral angle of the lateral ventricle with a "butterfly sign." In the experimental group,the ratio of double caudate nucleus to biphasic angle measured by magnetic resonance MRI was higher than that in the control group.The results were statistically significant.Compared with the control group,there was a negative correlation between the MMSE score and the Mo CA score and the ratio of BFR% and BCR% between the experimental group and the control group.The higher the ratio,the lower the MMSE and Mo CA scores.In the 13 patients with Huntington’s disease,the ratio of BFR% and BCR% in the high CAP group were larger than that in the low CAP group.Conclusion: The head MRI showed enlarged anterolateral angle of the ventricles and bilateral caudate nucleus atrophy.Magnetic resonance brain line measurement provides a simple and intuitive means for quantifying the local atrophy of brain tissue in patients with Huntington’s disease.There was a negative correlation between MMSE score and Mo CA score with BFR% and BCR%.The greater the ratio,the lower the MMSE and Mo CA scores.The CAP score can be clinically diagnosed in Huntington patients.In the high CAP group,the BFR% and BCR% were larger and the degree of caudate nucleus atrophy was higher than those in the low CAP group.