| Objective:To compare the efficacy of the two treatments in the prevention of deep vein thrombosis of the lower extremities after colorectal cancer surgery.Methods:120 cases of colorectal cancer patients from September 2015 to October 2017 admitted by general surgery of Qingdao municipal hospital were selected and surgical treatment was performed and the postoperative pathological diagnosis was performed.Among them,68 were males and 52 were females.All were examined before surgery,including medical history,physical examination,coagulation routine,tumor markers,and ultrasonography of the lower extremities.According to exclusion and inclusion criteria,120 patients with colorectal neoplasms were divided into two groups,60 in the control group and 60 in the observation group.In the control group,there were 32 males and 28 females,mean age(65.12±8.62)years.mean operation time(207.25±12.33)min.23 colon cancers and 37 rectal cancers.Observation group,36 males and 24 females,mean age(65.55±10.03)years,mean operation time(206.87±20.39)min,34 colon tumors,26 rectal cancers,There was no significant difference between the two groups in the general data(P>0.05),and they were comparable.Patients in the control group received only low-molecular-weight heparin drugs.Low-molecular-weight heparin calcium(hb)was given on the first postoperative day,once a day,4100iu/time,and continuous injection for 7 days.The observation group was treated with an intermittent air pressure therapeutic instrument on the basis of drug prevention and treatment.Air pressure was applied to the lower extremities.The patients were used on the first postoperative day,2 times a day,30 minutes each time,and continuous application for 5 days.The coagulation routines were reviewed before surgery and on 1,3,and 5 days after surgery.Preoperatively and on postoperative day 3 and 5,the blood vessels of the lower extremities were examined by ultrasonography to determine the presence or absence of deep vein thrombosis in the lower extremities.Normally distributed measurement data are expressed as mean ± standard deviation(X ± s).Comparisons between groups were compared using two independent samples t test.Count data were expressed as percentages,and comparisons between groups were performed using the X2 test.All tests used two-sided tests.p<0.05 was considered statistically significant.Results:There was no significant difference in prothrombin time,activated partial prothrombin time,fibrinogen,and D-dimer between the observation group and the control group before and at 1 and 3 days after operation(P>0.05).The content of fibrinogen and D-dimer in the observation group was significantly lower than that in the control group on the 5th day after operation(P<0.05).One case of left venous thrombosis occurred in the control group.The blood flow velocity of the two lower extremity femoral veins(right and left)was slightly slower than that before surgery in the two groups,but the blood flow velocity of the lower extremities was lower in the observation group than in the control group.The blood velocity of the two groups was improved and surpassed preoperatively on the 5th day after surgery.However,the blood velocity of the lower extremities in the observation group was still better than that of the control group,and the velocity of blood flow in the observation group was significantly higher than that in the control group(P<0.01).Conclusions:1.The patient showed hypercoagulable state on the first postoperative day(PT and APT increased significantly on the 1st postoperative day,while FIB and D-dimer decreased significantly).The fibrinogen and D-dimer in the observation group were significantly lower than those in the control group 5 days after the operation.2.Low molecular weight heparin calcium combined with air pressure treatment can significantly reduce postoperative hypercoagulability,and the lower limb venous blood flow velocity is significantly better than that of low molecular weight heparin alone.3.Therewas no significant difference in the incidence of postoperative thrombosis between the two groups in this study. |
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