Predictive Effect Of Chinese Visceral Adiposity Index For Type 2 Diabetes

Objective: To investigate the predictive value of Chinese visceral adiposity index(CVAI)for development of type 2 diabetes,and to compare its predictive power with alternate anthropometric measures(visceral adiposity index,VAI;BMI;Waist Circumference,WC;waist-to-hip ratio,WHR;waist-to-height ratio,WHtR).Methods: This was a community-based prospective study from 2008 to 2013.The study included 2383 subjects,aged 25-88.We used both the baseline and follow-up(2008-2013)data to assess the predictive power of CVAI,VAI,BMI,WC,WHR and WHtR by adjusting odds ratios(OR)and calculating the area under the receiver-operating characteristic(ROC)curve(AUC)for type 2 diabetes according to their quartiles.Results: There were 350(14.7%)subjects progressed to type 2diabetes during 5 years follow-up.The subjects who progressed to type 2diabetes showed significantly higher level of CVAI.Further logistic regression analysis showed that those with the second(OR = 1.66,95%CI:1.08-2.55,P<0.001),third(OR = 2.38,95%CI:1.58-3.57,P<0.001)and forth(OR = 6.19,95%CI:4.25-9.03,P<0.001)quartiles ofCVAI at baseline were more likely to develop into type 2 diabetes than those with the lowest quartiles of CVAI.AUC for CVAI(0.662 in male and0.738 in female)was significantly higher than for VAI,BMI,WC,WHR and WHtR.In addition,CVAI yielded the greatest Youden index in identifying type 2 diabetes in men(0.28)and women(0.36)among the six indices,and the optimal cut-offs for CVAI were 116.65/89.65 in men and women,respectively.Conclusion: CVAI was an independent predictor of type 2 diabetes in Chinese adults,and its predictive power was modestly superior to VAI,BMI,WC,WHR and WHtR.