| Objective: This study aimed to analyze the differences in the refractive state and optical compositions of preterm children with and without retinopathy of permaturity(ROP)at age 6,and to explore the changes of eye development in these children between 3 and 6 years of age.Methods:Preterm children who received fundus screening between January 2009 and February 2011 were recruited,and divided into ROP group and non-ROP group.and the control group was normal full moon after screening.Corneal refraction,radius of curvature,astigmatism,anterior chamber depth,lens thickness,vitreous thickness and axial length were measured.After ciliary muscle paralysis with 1% cyclopentanone,retinoscopy was performed.Above parameters were compared between two groups,and their relationships with gestational age and birth weight were further evaluated.The changes in refractive state and optical compositions were analyzed in children aged 3-4 years,5 years and 6 years,respectively.Results: A total of 250 eyes from 126 patients were included for analysis.There were 56 eyes from 29 preterm children in ROP group(stage1-3 prethreshold),104 eyes from 52 preterm children and 90 eyes from 45full-term children.The incidence of myopia was the highest in ROP group(8/56,14.28%),followed by non-ROP group(7/104,6.73%)and control group(2/90,2.22%).The incidence of hyperopia was the highest in control group(31/90,34.44%),followed by ROP group(18/56,32.14%)and non-ROP group(32/104,30.76%).The incidence of astigmatism ranged from high to low in the ROP group(24/56,42.85%),preterm labor group(19/104,18.27%),and the full moon group(8/90,8.89%).The corneal astigmatism(-1.48 DC,-1.15 DC,-1.04 DC,P<0.05)and mean astigmatism(1.09 DC,1.07 DC,0.55 DC,P<0.05)showed that the ROP and preterm group were more than the term group.Corneal refractive power(43.88 D,42.88 D,42.94 D,P < 0.05)showed the highest in ROP group.corneal curvature in ROP group increased significantly as compared to non-ROP group and control group(7.87 mm,7.66 mm and 7.65 mm,P<0.05);there was no marked difference in Lens thickness among three groups(4.40 mm,4.41 mm and 4.41 mm,P>0.05).The axial eye length in ROP group and non-ROP group reduced significantly as compared to control group(22.35 mm,22.36 mm,22.57 mm,P<0.05).Gestational weeks and birth weight was negative correlation with corneal astigmatism(r=-0.204,p=0.019;r=-0.278,p=0.001),astigmatism(r=-0.225,p=0.001;r =-0.282,p <0.001);But positive correlation with the axial length(r=0.258,p=0.005;r=0.252,p=0.001).At the same time,the birth weight was positively correlated with the equivalent spherical mirror(r=0.156,p=0.039).Corneal curvature(r=0.245,p=0.001)and corneal refractive power(r=-0.252,p=0.001)were all negatively correlated.The incidence of myopia increased and that of hyperopia reduced in children over age.In children aged 3-4years,each optical component significantly increased as compared to those aged 5 years(P<0.05);the vitreous thickness and axial eye length in children aged 5 years increased significantly as compared to those aged 6years(P<0.05),but the anterior chamber depth and lens thickness were comparable between them(P>0.05).Conclusion:(1)This 6-year-old data showed shows the incidence of myopia and astigmatism were high in preterm and ROP children..(2)the development of various optical components in the eye affected by low birth weight,preterm birth and ROP,resulting in myopia and astigmatism.(3)The incidence of myopia increases,but that of hyperopia reduces over age,and the anterior chamber depth,lens thickness,vitreous thickness and axial eye length tend to increase over age in children aged 3-6 years. |
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