Relationship Between Internal Carotid Artery Curvature And Intracranial Aneurysm

Objective: To observe the occurrence of internal carotid artery curvature in patients with intracranial aneurysm,and to investigate whether there is correlation between internal carotid artery curvature and intracranial aneurysm.Methods: The general case data of 177 patients with aneurysms(Patients with ruptured aneurysms and unruptured aneurysms)and 164 patients without aneurysms(control patients)were retrospectively analyzed by case-control study.The internal carotid artery curvature was divided into no,tortuosity,kinking and coiling by CTA(Computed tomogrphy angiography)images.The distribution of internal carotid artery curvature was described,and the incidence of internal carotid artery curvature in different age groups and different sexes was compared.Univariate analysis was performed on the degree of carotid artery tortuosity and general data between the aneurysm group and the control group,and the multivariate Logistic regression analysis was used to analyze the statistical significance factors of univariate analysis.The correlation between aneurysm-relatedfeatures and internal carotid artery curvature was analyzed.Results:1.In this study,continuously included 164 cases in the control group,the average age was 62.1?12.3 years,and the proportion of women was59.1%.There were a total of 328 internal carotid arteries,the rates of normal,tortuosity change,kinking change and coiling change were respectively 16.2%,69.5%,12.2% and 2.1%.177 consecutive patients were included in the intracranial aneurysm,with a mean age of 56.7?9.8years and a female ratio of 70.6%.There were a total of 354 internal carotid artery,the incidences of normal,tortuosity change,kinking change and coiling change were respectively 24.5%,55.4%,16.7% and 3.4%.2.In the intracranial aneurysm group and the control group,the incidence of tortuosity change of the internal carotid artery increased with increasing age,reached a peak in the 50-59 age group,and then the incidence was decreased.The incidence of internal carotid artery kinking change increased with age,and a small decrease in the 50-59 age group,and then increased with age.The incidence of internal carotid artery coiling changes increased with age in the control group,while in the intracranial aneurysm group,the incidence of coiling changes reached the peak in the40-49 age group,and then decreased with age.3.In the intracranial aneurysm group and the control group,the occurrence rate of kinking change in the ≥60-year-old population wassignificantly higher than that in the <60-year old group(P=0.001,P<0.001),and the female population of internal carotid artery kinking change incidence rate was significantly higher than that of the male population(P=0.001,P=0.001).4.Univariate analysis showed that the proportion of females in the intracranial aneurysm group and the incidence of kinking change in the internal carotid artery were significantly higher than those in the control group(P<0.05),the average age of intracranial aneurysms was significantly lower than that of the control group(P<0.05).There was no significant difference in the incidence of hypertension,diabetes,coronary artery disease,smoking,alcohol consumption,internal carotid tortuosity or coiling change(P>0.05).5.Multivariate Logistic regression analysis showed that the kinking change of internal carotid artery was an independent risk factor for intracranial aneurysms(OR= 2.573,95% CI=1.426-4.641,P=0.002).6.In the analysis of the correlation between the characteristics of intracranial aneurysm and internal carotid artery curvature,there was no correlation between the type of internal carotid artery curvature and intracranial aneurysm rupture,size and number(P>0.05).Conclusion:1.The incidence of tortuosity change of the internal carotid artery increased with increasing age,reached a peak in the 50-59 age group,andthen the incidence was decreased.The incidence of internal carotid artery kinking change increased with age,and a small decrease in the 50-59 age group,and then increased with age.2.The occurrence rate of kinking change in the ≥60-year-old population was significantly higher than that in the <60-year old group,and the female population of internal carotid artery kinking change incidence rate was significantly higher than that of the male population.3.Internal carotid artery kinking change is significantly associated with intracranial aneurysms.4.There was no correlation between carotid artery curvature and intracranial aneurysm rupture,size and number.