Micro-RNA And Hypoxic Ischemic Encephalopathy

Hypoxic ischemic encephalopathy(HIE)refers to the lack of suffocate in the perinatal period ischemic damage,including nerve pathology and pathophysiology process of characteristic,and is clinically appear a series of encephalopathy.Some children can have different degrees of neurological sequelae,which is one of the important diseases that endanger the quality of life of children in China.To explore the pathogenesis and repair mechanism of HIE is of great significance to the clinical diagnosis and treatment of HIE.At present,the sensitivity and specificity of the serum markers in HIE are analyzed,and the new biological monitoring indexes need to be further explored.Mi RNA is one of the popular researches today,and plays an important role in the development of many neurological diseases.Mi RNA with target gene 3’-untranslated region,degradation of m RNA or inhibit the translation process,regulate target gene expression,which involved in the cell,proliferation,differentiation,growth,biological processes such as metabolism and apoptosis regulation.The study found that there are specific and abundant mi RNA in the brain that regulate at least 30 percent of the protein coding genes in the brain.Further studies have shown that these mi RNAs are associated with neuronal differentiation,brain development,and advanced neurological functions.With the in-depth study of mi RNA,mi RNA has been proved to be associated with cerebral hypoxia ischemic injury,and mi RNA analogue or antagonist can play an important role in the diagnosis and treatment of neurological diseases.In this paper,the relationship between HIE and mi RNA is described from HIE pathological changes and treatment,and new ideas for HIE diagnosis and treatment are provided.