| Objective: To study the changes of plasma ox-LDL before and after PCI in CHD patients and the effects of different doses of atorvastatin on ox-LDL.Methods:Patients with CHD were divided into non-CHD group and CHD group according to the results of coronary angiography.The latter were divided into PCI group and non-PCI group according to whether PCI was performed or not.Each group of patients was given randomized to 20 mg or 40 mg atorvastatin after surgery.Plasma ox-LDL levels were measured before and 72 hours after surgery in each group.The experimental data of each group were processed with SPSS220.0 software.The measurement data satisfying normality and variance were expressed as mean±standard deviation(`X±SD).The paired t-test was used for intragroup comparison,and the independent samples t-test were used for comparison between groups.Results:Ox-LDL levels in CHD group were higher than those in non-CHD group(33.86±9.85 vs.26.55±4.58,P<0.05).In the non-PCI group of CHD group,the plasma ox-LDL level was high in the low-dose atorvastatin group.Preoperative(38.48±9.21 vs.33.61±0.66,P<0.05),the plasma ox-LDL levels in the high-dose atorvastatin group were lower than before surgery(32.78±10.60 vs.36.19±9.41,P<0.05).In the PCI group,the plasma ox-LDL levels in the low-dose atorvastatin group were significantly higher than those preoperatively(39.93±9.35 vs.31.11±10.18,P<0.05).High-dose atorvastatin group There was no significant difference between preoperative and postoperative(34.16±10.52 vs.39.35±8.35,P>0.05);the difference of ox-LDL preoperative and postoperative levels in PCI group was higher than that in non-PCI group(5.18±12.72 vs.3.41±7.34,P<0.05).Conclusions: Atherosclerotic plaque stability is worse in patients with CHD than non-CHD patients;PCI is more likely to aggravate atherosclerotic plaque instability than angiography alone;high-dose atorvastatin have tronger effect in plaques stability than low-dose. |
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