Analysis Of Risk Factors For Residual Lesions After Conization

Objective:To explore risk factors for residual lesions after conization in patients with cervical high-grade squamous intraepithelial lesions(HSIL)and microinvasive cervical cancer.Methods:122 patients with cervical HSIL or microinvasive cervical cancer were involved,who underwent conization and hysterectomy.The relations between residual lesions and age,menopausal status,parity,high-risk human papilloma virus(HR-HPV)types,methods of conization,grade of lesions,glandular involvement,extent of lesions,margin status were assessed.Statistic data were analyzed by chi-squared test and logistic regression analysis.Results:30.3%(37/122)patients were found residual lesions in uterus specimens.Univariate analysis showed that multiple HR-HPV infection(P=0.001,?~2=10.669),microinvasion(P=0.014,?~2=6.052),positive margins(P=0.000,?~2=15.006)were risk factors of residual lesions after conization.Multivariate analysis showed that multiple HR-HPV infection(P=0.002,OR=4.282,95%CI 1.674~10.949),positive margin(P=0.001,OR=4.505,95%CI1.823~11.138)were independent risk factors of residual lesions after conization.Conclusion:The patients with multiple HR-HPV infection and positive margin are at high-risk of residual lesions.Enhanced management and close follow-up are necessary for detecting residual lesions early.