Health Economic Evaluation Of Measles-Mumps-Rubella Combined Vaccine Immunization Strategy Among The Prevention And Treatment Of Mumps In Shenyang

Objective:Understand Shenyang,mumps the economic burden of disease of patients.Conduct the health economic evaluation of MuCV immunization strategy.Methods:Descriptive epidemiological methods were used to analyze the distribution characteristics of the time,region and population of mumps in Shenyang.Based on interrupted time series analysis（ITSA）data,a segmented regression model was used to analyze the trend of Mumps incidence in Shenyang.The measles mumps rubella combined attenuated live vaccine（MMR）was calculated and the number of Mumps was avoided after the national expanded immunization program（NEPI）.Through a retrospective survey of Mumps confirmed cases,the economic burden of Mumps patients in Shenyang was understood.Collect the existing data,calculate the immune cost of Mumps prevention and cure in Shenyang,use the cost-effectiveness,cost-benefit and cost utility analysis method of health economics evaluation to evaluate the economic and social benefits of MMR inoculation against Mumps in Shenyang.Result:1.2004-2016,17853 cases of mumps were reported in Shenyang.The annual incidence rate is 37.2547/10 million.The epidemic situation is decreasing gradually in the cyclical fluctuation.May-June and December-the next January were the peak of the disease.The main cases were 5-year old and 10-year old children.The main occupational distribution was school students.2.The monthly incidence of Mumps was decreased before MMR was brought into NEPI,and the average monthly decreased by 0.0085/10 million,with no statistical difference.After the vaccination,the incidence of Mumps decreased immediately,and the difference was statistically significant（β₂=-1.1926,P=0.0188）.The slope of the difference before and after the vaccination was 0.0288（β₃）and the two stage slope difference was statistically significant（P=0.0238）.3.A total of 150 Mumps patients in Shenyang were investigated in 2017.The direct economic burden of inpatients and non hospitalized cases was 5343.29 yuan and 863.36 yuan respectively,the average indirect economic burden of each case was 1522.41 yuan,the total economic burden of each case was3724.61 yuan,and the average case loss was 0.01411 DALY per case.4.Since the introduction of MMR into NEPI,a total of 10224 cases of mumps have been reduced.The cost-effectiveness ratio is 1:15.37（case/million yuan）,net benefit is 31 million529 thousand yuan,the benefit cost is 5.72,the incremental cost effect is 46 thousand and 100 yuan per DALY.Conclusion:1.inoculation of MuCV is the most effective means to prevent Mumps.The incorporation of MMR into NEPI can reduce the incidence of Mumps.2.The economic burden of hospitalized cases of Mumps in Shenyang is heavy.3.The integration of MMR into NEPI has achieved good economic benefits and high cost utility.