Lactate Burden As An Independent Predictor For Hospital Mortality In Patients With Community-Acquired Pneumonia

Objective: To investigate the prognostic value of lactate burden in community-acquired pneumonia(CAP)patients.Methods:A total of 57 patients with CAP(male: n=48,84.2% vs female: n=9,15.8%)admitted to the First Affiliated Hospital of Soochow University from Mar.2015 to Feb.2017 were enrolled.They were divided into an observation group(n=15,26.3%)of hospital mortality and a control group(n=42,73.7%).The highest daily lactate values during the first 7 days of hospitalization were collected.The levels of serum uric acid were measured from the vein blood in the morning of the 2nd day after admission.Clinical data were analyzed by univariate and multivariate logistic regression model.Results:The lactate burden level of observation group was significantly higher than the control group[4.3(0.6,15.95)vs.0(0,1.08),p=0.005].Gender(OR=0.572,95%CI:1.119~2.406,P=0.667)、Age(OR=1.004,95%CI:0.934~1.079,P=0.918)and CURB-65 score(OR=1.368,95%CI:0.600~3.120,P=0.457)were all determined as the independent risk factors of hospital morality by multivariate logistic regression model.Conclusions:Lactate burden is an independent risk factor for hospital mortality in patients with CAP.The CAP patients with early onset of high levels of lactate burden will have increased poor outcome risk.Patients with high level of lactate burden at admission should be paid more attention,and effective measures should be taken for them.