Analysis Of Clinical Features Of 537 Patients With Alcoholic Liver Diseases

Objective:Clinical data on 537 patients with alcoholic liver diseases were analyzed retrospectively to understand the clinical features of alcoholic liver diseases,especially severe alcoholic hepatitis,alcoholic cirrhosis and alcohol-related liver cancer.This study aimed to provide regional data to understand the general characteristic of alcoholic liver diseases in China,and to provide evidence to improve the diagnosis and treatment of alcoholic liver diseases,especially severe alcoholic hepatitis,alcoholic cirrhosis and alcohol-related liver cancer.Methods:Clinical data on 537 alcoholic patients admitted to the Department of Hepatology of the First Hospital of Jilin University between March 2012 and August 2017 were analyzed retrospectively.The SPSS 20.0 software and Excel table were used for all analysis.Results:1.The changing trends of alcoholic liver diseases in hospitalized patients in department of hepatology:From 2013 to 2016,among the patients with major chronic liver diseases(HBV-related liver diseases,HCV-related liver diseases,alcoholic liver diseases,autoimmune liver diseases)hospitalized in the Department of Hepatology of the First Hospital of Jilin University,the proportion of alcoholic liver diseases was10%,11%,9%,and 7%in each year respectively.2.Composition distribution of 572 cases with alcoholic liver diseases:Among 572patients with alcoholic liver diseases(including 35 cases with incomplete clinical data),478 cases(83.6%)with alcoholic cirrhosis.3.Basic information and clinical data on 537 cases with alcoholic liver diseases:Basic information:Among 572 patients with alcoholic liver diseases,537 cases with complete clinical data,including 521 males(97.0%)and 16 females(3.0%),the ratio of the male to female was 32.56:1.The age of alcohol-related liver cancer group was significantly higher than alcoholic hepatitis group(t=-3.6,P=0.001).The years of alcohol intake of alcohol-related liver cancer group was higher than alcoholic cirrhosis group(Z=-2.9,P<0.05).Clinical data:GGT was increased in 383 cases(71.3%),AST was increased in 304cases(56.6%).4.Basic information and clinical data on 456 cases with alcoholic cirrhosis:Basic information:Among 456 patients with alcoholic cirrhosis,441 cases were male(96.7%),15 cases were female(3.3%),the ratio of male to female was 29.4:1.Clinical data:Compared with HBV-related cirrhosis group,the level of ALP(Z=-3.2,P=0.001),GGT(Z=-4.8,P<0.001),TBIL(Z=-4.4,P<0.001),WBC(Z=-2.2,P<0.025)and Neutrophil(Z=-2.1,P=0.031)were significantly elevated in our study;compared with HCV-related cirrhosis group,ALP(Z=-3.0,P=0.002),GGT(Z=-4.9,P<0.001),TBIL(Z=-5.3,P<0.001),WBC(Z=-3.7,P<0.001),and Neutrophil(Z=-3.8,P<0.001)were significantly elevated in our study.5.Clinical characteristics of primary liver cancer:Between March 2012 and August 2017,1423 patients with primary liver cancer were admitted by our department of multidisciplinary consultation.Removing the repeated cases,1074 cases(75.4%)with HBV-related liver cancer,70 cases(4.9%)with alcohol-related liver cancer.Among 70 patients with alcohol-related liver cancer,9 were excluded with incomplete clinical data.All 61 patients were male.Positive rate of AFP in our group was significantly lower than HBV-related liver cancer group(c~2=44.7,P<0.001),HCV-related liver cancer group(c~2=21.2,P<0.001);number of tumors in our group was significantly lower than HBV-related liver cancer group(c~2=46.1,P<0.001),HCV-related liver cancer group(c~2=33.5,P<0.001);rate of portal system thrombosis was significantly lower in our group than HBV-related liver cancer group(c~2=27.6,P<0.001)and HCV-related liver cancer group(c~2=6.63,P=0.02);Child-Pugh grading was significantly lower in our group than HBV-related liver cancer group(c~2=54.6,P<0.001),HCV-related liver cancer group(c~2=38.9,P<0.01).6.Clinical characteristics of 101 cases with severe alcoholic hepatitis:Among 537patients with alcoholic liver diseases,101 cases with severe alcoholic hepatitis(18.8%).Among 101 cases,98 cases(97%)with liver cirrhosis.There were 97 males(96%),4 females(4%).Among incentives of severe alcoholic hepatitis,gastrointestinal hemorrhage was identified in 16 cases(15.8%).Renal failure was presented in 49 cases(48.5%).Conclusions:1.Alcoholic cirrhosis was more common in hospitalized patients in department of hepatology.According to gender,male account for the majority.Age were older and alcohol intake years were longer in patients with alcohol-related liver cancer.2.Enzyme of alcoholic liver diseases was mainly increased by GGT?AST.TBIL?WBC?Neutrophil were significantly increased in alcoholic cirrhosis group.3.Positive rate of AFP,rate of portal system thrombosis,Child-Pugh grading were significantly lower in alcohol-related liver cancer group.4.Gastrointestinal hemorrhage is the common incentive of SAH.Renal failure is common in cases with organ failures.