Comparison Of Survival Rate Between Anti-hydatid Agents And The Combination Of Palliative Surgery And Anti-hydatid Agents For Hepatic Alveolar Echinococcosis:a Meta-analysis

Objective: To investigate the survival rates of advanced hepatic alveolar echinococcosis(HAE)patients using anti-hydatid agents and the combination of palliative surgery and anti-hydatid agents.Methods: Literature search was performed from the PubMed,Embase,Cochrane liabrary,CBM,VIP database,Wanfang database,CNKI database.The language was limited to Enligh and Chinese.Analysis was coducted to the survival rates of advanced HAE patients using anti-hydatid agents compared to the counterparts using palliative surgery and anti-hydatid agents.Results:Twelve articles were included in the meta analysis,including 3 articles in English and 9 in Chinese.A total of 675 patients(male: 352,female: 241)were enrolled(T-able2).Among the 675 cases,157(23.25%)received surgery,10(1.48%)received minimally invasive surgery,261(38.67%)received palliative surgery and anti-hydatidagents,225(33.33%)received agents as they were not recommended to receive surgery.No statistical difference was noticed in the 3-year survival[RR=1.23,95%CI [0.90,1.68],P=0.20>0.05] and 5-year survival [RR=1.18,95%CI[0.88,1.57],P=0.27 > 0.05] between the patients received anti-hydatid agents compared to the counterparts using palliative surgery and anti-hydatid agents.Conclusions: Oral administ-ration of anti-hydatid agents showed similar treatment efficiency with that of the combination of palliative surgery and anti-hydatid agents.