Study On The Correlation Between The Bone Mineral Density And The Content Of Metal Elements At Different Parts Of Hip In Postmenopausal Women

Objective:To explore the relationship between the content of metal elements(Ca,Fe,Mg,Zn,Cu,Mn)in different parts of the hip and the change trend of bone density in the corresponding parts of the hip in postmenopausal women with hip fracture.Method:In January 2012-September 2017,collecting 82 cases of femoral neck fracture of hip replacement in postmenopausal women with data,the second day after admission in patients with empty stomach serum specimens of determination of serum bone metabolic index and routine blood,biochemical index;Test metal element(Ca,Fe,Mg,Zn,Cu,Mn)content(ICP-MS)from the femoral head and femoral trochanter bone after hip replacement,measuring the density of the hip and lumbar vertebrae after surgey a week(DXA).The relevant data were analyzed statistically.Results:The bone density in different parts of the hip was different,which was statistically significant(P<0.001).There was a difference in the content of metallic elements(calcium,magnesium,iron,zinc)in different parts of the hip(P<0.05).Multiple stepwise regression analysis suggest age,bone calcium,bone iron,ALP,BMI,bone magnesium can enter the femoral neck BMD regression model(R~2=0.478),age,bone calcium,magnesium,iron,BMI,β-CTX can enter the great trochanter bone mineral density regression model(R~2=0.526).The partial correlation analysis after controlling age,BMI and other factors suggested that bone calcium and bone magnesium were positively correlated with bone density,and bone iron was negatively correlated with bone density.Conclusion:Bone density in patients with hip fragility fracture was influenced by age,BMI,bone metal elements and some bone metabolism indexes.In addition,increase of bone iron,decrease of bone calcium and magnesium are independent risk factors for bone loss.The increase of bone iron was significantly associated with decreased bone mass,and the decrease of bone calcium and magnesium was significantly associated with decreased bone mass.The study confirmed the study of the correlation between iron accumulation and osteoporosis.