Oxycodone Versus Fentanyl For Patient-controlled Intravenous Analgesiaafter Laparoscopic Gynecological Surgery

Objective: To investigate the efficacy and tolerability of oxycodone versus fentanyl in patients with patient-controlled intravenous analgesia(PCIA)after laparoscopic gynecological surgery.Methods: 72 patients who will take laparoscopic gynecological surgery,are randomly divided into oxycodone group(O,n=36)and fentanyl group(F,n=36)(potency ratio 50:1),The patients received 0.1 mg/kg oxycodone or 2ug/kg fentanyl at the end of the surgery.After the operation,the pain level of all patients was in the same standard,that is,NRS = 3 points,and PCIA pump was opened.Group O analgesic pump formula is oxycodone 0.8mg/kg+tropisetron 10 mg,diluted with 0.9% physiological saline to 100ml;Group F analgesic pump formula is fentanyl 16ug/kg+ tropisetron 10 mg,with 0.9%physiological saline to 100 ml,The setting parameters are: loading dose 2ml,background dose 2ml/h,PCA volume 2ml/ times,locking 15 minutes.TheNRS was evaluated for the patients in rest and in moving and visceral pain at1 h,4h,8h,12 h,24h,48 h after surgery,sedation scores,patient satisfaction,and side effects were record.The conditions of remedial analgesia and remedial emetic were recorded.The first time of anus exhaust after the operation was recorded.Results: The NRS score of group O was significantly lower than that of group F at the time of 8h,12 h after surgery when resting and at the time of 1h,4h,8h,12 h after surgery during the movement and visceral pain at 12 h,24h after surgery(P <0.05);The incidence of postoperative nausea and dizziness(PONV)was significantly higher in group F than in group O(P<0.05);Patient satisfaction was significantly higher in group O than in group F during the 48 hours after surgery(P < 0.05);There was no severe PONV,respiratory depression and other serious adverse events in both group O and group F.Conclusions: Oxycodone for PCIA(potency ratio 50:1)provided superior analgesia to fentanyl for PCIA after laparoscopic gynecological surgery,Oxycodone not only provides better postoperative pain relief,and less side effects.