Correlations Between The Effect Of Aclasta Treating Vertebral Osteoporosis And Iron Accumulation

OBJECTIVE: To investigate the correlations between the effect of Aclasta treating vertebral osteoporosis and iron accumulation.METHODS: The patients with osteoporosis were prospectively admitted to our study from January 2013 to February 2015 in our hospital,67 patients were enrolled in a two-year follow-up eventually.We measure the first time and the second time,bone mineral density and serum ferritin(Ferritin/Fer),bone metabolic index and biochemical index.According to serum Fer levels,the patients were divided into the normal group and the elevated group.The difference of bone mineral density between the two groups was analyzed by student t’ test in the normal group(Fer≤150 ug / L)and the increased group(Fer> 150 ug/L).The correlation between serum Fer and the increase of bone mineral density in patients with Aclasta was verified by human linear correlation analysis,multiple stepwise regression analysis and partial correlation analysis.Results: The bone mineral density of vertebral bone in the normal group was significantly higher than that in the elevated group(P<0.05).There was a negative correlation between serum Fer and the bone mineral density of vertebral bone(r=-2.469,P<0.05).Adjustment for confounding factors,the level of serum Fer was still negatively correlated with the growth of vertebral bone mineral density treated by Aclasta(r=-0.239,P <0.05).CONCLUSION: Iron accumulation is not beneficial to the improvement of osteoporotic vertebral bone density treated by Aclasta.The results will provide a new clinical evidence-based medical basis for iron reduction treatment.