The Effects Of Obesity On Male Sexual Function And Damage Of Sperm

Objective:To analyze and explore the effects of obesity on male sexual function and sperm.Methods:In December 2016,medical examiners of married men in the medical center of the Second Affiliated Hospital of Jilin University,the use of "premature ejaculation diagnostic scale(PEDT)","erectile function quality scale(QEQ)," " IIEF-5 of erectile dysfunction scale" to research male sexual function.A single factor variance analysis(ANOVA)was used to compare the multiple groups of measured data in the normal distribution.The two of the samples were compared with the q test(SNK method);the non normal distribution of the measurement data was compared with the non parametric test(Kruskal-Wallis H test);the enumeration data was compared with the trend chi square test.The analysis of influence factors of premature ejaculation was analyzed by logistic regression analysis,and the factors of erectile functional quality(hardness)and erectile dysfunction were analyzed by multiple linear regression respectively.In January 2017 at the Jilin University Second Hospital Reproductive Center patients were randomly selected from 51 male whose BMI>28kg/m2 as the obesity group,42 male whose 18.5 kg/m5≤BMI<24 kg/m2,as the normal group.The study objects were collected for semen detection,and detected LDH,SOD,MDA,MMP,complex Ⅰ,complex Ⅱ,complex Ⅲ,complex Ⅳ and complex V in semen.Results:The epidemiological survey found that sexual life frequency in normal,overweight and obese groups were(1.63±0.70)times/month,(1.60±0.70)times/month and(1.22±0.65)times/month,had significant difference(F=9.330,P<0.01),sexual life frequency in obesity group was lower than normal group(P<0.05).Scores of premature ejaculation in obese and overweight groups were higher than the normal group respectively(P<0.05);the ratio of married male premature ejaculation from normal group to the obese group was increased(trendχ2=12.837,P<0.01);BMI was a risk factor for premature ejaculation(OR=1.080,P<0.01),and the frequency of sexual life was a protective factor(OR=0.452,P<0.05).The quality(hardness)of erectile function in obese group was lower than that of normal group(P<0.05)and the quality(hardness)of erectile function in overweight group was lower than that of normal group(P<0.05);The ratio of erectile function quality(hardness)of married male had an increasing trend from normal group to obese group with increasing BMI(trend χ2=19.247,P<0.01);the scores of erectile function quality(hardness)decreased with increasing BMI(β=-0.703,P<0.01);Sexual frequency and age also affected the quality(hardness)of erectile function of married men.Erectile function scores in obesity group was less than the overweight and normal group(P<0.05),overweight group and normal group had no significant difference(P>0.05);the ratio of married male erectile function from normal group to obese group had increasing trend(trend χ2=12.351,P<0.01);scores of married male erectile function decreased with the increase of BMI(β=-0.115,P<0.05);Age also affected male erectile function.Male sperm damage detection results:compared with normal group,semen concentration of obese group was lower(P<0.01),the number of abnormal sperm counts was increased(P<0.01),sperm progressive exercise(A+B)was decreased;compared with normal group,obese semen LDH release rate increased(P<0.01),the level of SOD in the semen of the obese group was significantly lower(P<0.01),the level of MDA in semen was increased(P<0.05);compared with normal group,the activity of sperm mitochondrial complex Ⅱ and Ⅴ in obese group was lower(P<0.05),the activity of mitochondrial membrane potential decreased(P<0.05).Conclusion:Obesity not only promotes and causes sexual dysfunction in men,but may also decrease the quality and quantity of male sperm by reducing the mitochondrial activity caused by oxidative damage.